Congenital PCB poisoning: a reevaluation
A review of the literature reveals a need to clarify the pathologic physiology of congenital polychlorinated biphenyl (PCB) poisoning, which is characterized by intrauterine growth retardation, brown staining of the skin and mucous membranes as in Addison's disease, natal teeth, widely open fontanelles and sagittal suture and apparent overgrowth of the gingiva. The skull abnormalities may represent irregular calcification, with natal teeth appearing because the bone of the mandible is penetrated more easily than usual. Some fetuses were poisoned at the time the mothers ingested the oil; others were affected in the subsequent years from residual contamination in the mothers' bodies. The misadventure in Japan was repeated in Taiwan in 1979. The seven congenital cases in Taiwan reported thus far seem to differ from those in Japan. In Taiwan the noses were somewhat black, two of the infants did not have low birth weight and the osseous abnormalities of the skull and gingival hyperplasia were not observed. Systematic followup studies should be made in Taiwan of the children born within 2 years of maternal poisoning with PCBs. Special attention should be given to age at first dentition and skull-X-rays for spotty calcification, among other measures of physical, neurologic and intellectual development.
- Research Organization:
- National Cancer Institute, Bethesda, MD
- OSTI ID:
- 6330479
- Journal Information:
- Environ. Health Perspect.; (United States), Vol. 60
- Country of Publication:
- United States
- Language:
- English
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Growth and development of permanent teeth germ of transplacental Yu-Cheng babies in Taiwan
OSTEOMYELITIS OF THE MANDIBLE FOLLOWING IRRADIATION
Related Subjects
ANIMAL GROWTH
INHIBITION
CHLORINATED AROMATIC HYDROCARBONS
HEALTH HAZARDS
PRENATAL EXPOSURE
MUCOUS MEMBRANES
PATHOLOGICAL CHANGES
SKIN
SKULL
TEETH
VEGETABLE OILS
CONTAMINATION
ENVIRONMENTAL EXPOSURE PATHWAY
FETUSES
FOOD
INFANTS
INGESTION
JAPAN
MEDICAL SURVEILLANCE
PATHOLOGY
PHYSIOLOGY
REVIEWS
TAIWAN
WEIGHT
WOMEN
AGE GROUPS
ANIMALS
AROMATICS
ASIA
BODY
CHILDREN
DIGESTIVE SYSTEM
DOCUMENT TYPES
FEMALES
GROWTH
HALOGENATED AROMATIC HYDROCARBONS
HAZARDS
INTAKE
ISLANDS
MAMMALS
MAN
MEMBRANES
OILS
ORAL CAVITY
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
PRIMATES
SKELETON
SURVEILLANCE
VERTEBRATES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)