Method of magnetic resonance imaging of the liver and spleen
A method is described of imaging a tumor in the liver or spleen of a human subject, comprising: (a) parenterally administering to the human subject prior to magnetic resonance imaging (MRI) examination an aqueous suspension composed essentially of 1.5 to 8 micron diameter microspheres, the microspheres having a biodegradeable matrix with a contrast agent dispersed therein selected from the group consisting of paramagnetic and ferromagnetic contrast agents. The quantity of the microspheres, administered are effective to appreciably reduce the T/sub 2/ relaxation time of the subjects liver and/or spleen; (b) delaying the examination until the microspheres have been segregated by the reticuloendothelial system and are concentrated in the liver and spleen; and then (c) carrying out an MRI examination of the liver and/or spleen by T/sub 2/ imaging or mixed T/sub 1/ and T/sub 2/ imaging to obtain an image in which the normal liver or spleen tissues appear dark and the tumor appears light with distinct margins.
- Assignee:
- Molecular Biosystems, Inc., San Diego, CA
- Patent Number(s):
- US 4675173
- Application Number:
- TRN: 87-030582
- OSTI ID:
- 6324734
- Resource Relation:
- Patent File Date: Filed date 8 May 1985
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LIVER
NEOPLASMS
NMR IMAGING
SPLEEN
AQUEOUS SOLUTIONS
FERROMAGNETIC MATERIALS
HUMAN POPULATIONS
IMAGE PROCESSING
IMAGES
MAGNETIC RESONANCE
MICROSPHERES
PARAMAGNETISM
RELAXATION TIME
RETICULOENDOTHELIAL SYSTEM
ANIMAL TISSUES
BODY
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DISPERSIONS
GLANDS
MAGNETIC MATERIALS
MAGNETISM
MATERIALS
MIXTURES
ORGANS
POPULATIONS
PROCESSING
RESONANCE
SOLUTIONS
TISSUES
550602* - Medicine- External Radiation in Diagnostics- (1980-)