Persistent uptake of indium-111-antimyosin monoclonal antibody in patients with myocardial infarction

Journal Article · Thu Nov 01 00:00:00 EST 1990 · American Heart Journal; (USA)

DOI:https://doi.org/10.1016/0002-8703(90)90113-C· OSTI ID:6322825

Matsumori, A; Yamada, T; Tamaki, N; Kawai, C; Watanabe, Y; Yonekura, Y; Endo, K; Konishi, J; Yoshida, A; Tamaki, S ^[1]

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1. Kyoto Univ. (Japan)

Indium-111(111In)-antimyosin scintigraphy was investigated in 27 patients with myocardial infarction. {sup 111}In-antimyosin Fab was administered intravenously, and planar and single photon emission computed tomographic images were obtained 48 hours later. Uptake of {sup 111}In-antimyosin was present in 9 of 10 patients (90%) studied within 6 days of infarction. During the second week positive scans were seen in 16 of 16 patients (100%) including 13 (81%) who had normal creatine kinase levels. The mechanism of persistent positive antimyosin images in the subacute stage of myocardial infarction remains to be clarified. {sup 111}In-antimyosin scintigraphy may be useful as a noninvasive method for the detection of myocardial injury late and early after a suspected acute myocardial infarction.

• OSTI ID: 6322825
• Journal Information: American Heart Journal; (USA), Vol. 120:5; ISSN 0002-8703
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
HEART
RADIOIMMUNOSCINTIGRAPHY
MYOCARDIAL INFARCTION
DIAGNOSIS
INDIUM 111
MONOCLONAL ANTIBODIES
MYOSIN
PATIENTS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
ANTIBODIES
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
GLOBULINS
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOIMMUNODETECTION
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
TOMOGRAPHY
TRACER TECHNIQUES
550601* - Medicine- Unsealed Radionuclides in Diagnostics