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Title: Anti-LPS antibodies reduce endotoxemia in whole body Co-60 irradiated primates - A preliminary report

Abstract

A previously established primate model was used to evaluate the role of lipopolysaccharide (LPS, endotoxin) in radiation sickness. Vervet monkeys were Co-60 irradiated with an LD100 exposure and had periodic blood samples taken for the determination of LPS and anti-LPS lgG antibodies and for bacteriological studies. On day 2 postirradiation, primates were treated with either sterile 0.9 percent saline, or equine anti-LPS hyperimmune plasma, or tripotassium-dicitrato-bismuthate (Denol). Results indicate that anti-LPS-treated animals survived significantly longer than both the other groups and, since LPS may cause nausea, vomiting, diarrhea, anorexia, and headaches, it is suggested that Anti-LPS administration may be of value in reducing plasma LPS concentration in humans and improving their performance and survivability. 24 refs.

Authors:
; ; ; ;  [1]
  1. Natal Univ., Durban (South Africa)
Publication Date:
OSTI Identifier:
6320539
Resource Type:
Journal Article
Journal Name:
Aviation, Space and Environmental Medicine; (USA)
Additional Journal Information:
Journal Volume: 61; Journal ID: ISSN 0095-6562
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ANTIBODIES; RADIOSENSITIVITY EFFECTS; MONKEYS; BIOLOGICAL RADIATION EFFECTS; COBALT 60; COSMIC RADIATION; ETIOLOGY; RADIATION INJURIES; SPACE; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; COBALT ISOTOPES; INJURIES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; PRIMATES; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOT; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Wells, M T, Gaffin, S L, Wessels, B C, Brock-Utne, J G, and Jordaan, J P. Anti-LPS antibodies reduce endotoxemia in whole body Co-60 irradiated primates - A preliminary report. United States: N. p., 1990. Web.
Wells, M T, Gaffin, S L, Wessels, B C, Brock-Utne, J G, & Jordaan, J P. Anti-LPS antibodies reduce endotoxemia in whole body Co-60 irradiated primates - A preliminary report. United States.
Wells, M T, Gaffin, S L, Wessels, B C, Brock-Utne, J G, and Jordaan, J P. 1990. "Anti-LPS antibodies reduce endotoxemia in whole body Co-60 irradiated primates - A preliminary report". United States.
@article{osti_6320539,
title = {Anti-LPS antibodies reduce endotoxemia in whole body Co-60 irradiated primates - A preliminary report},
author = {Wells, M T and Gaffin, S L and Wessels, B C and Brock-Utne, J G and Jordaan, J P},
abstractNote = {A previously established primate model was used to evaluate the role of lipopolysaccharide (LPS, endotoxin) in radiation sickness. Vervet monkeys were Co-60 irradiated with an LD100 exposure and had periodic blood samples taken for the determination of LPS and anti-LPS lgG antibodies and for bacteriological studies. On day 2 postirradiation, primates were treated with either sterile 0.9 percent saline, or equine anti-LPS hyperimmune plasma, or tripotassium-dicitrato-bismuthate (Denol). Results indicate that anti-LPS-treated animals survived significantly longer than both the other groups and, since LPS may cause nausea, vomiting, diarrhea, anorexia, and headaches, it is suggested that Anti-LPS administration may be of value in reducing plasma LPS concentration in humans and improving their performance and survivability. 24 refs.},
doi = {},
url = {https://www.osti.gov/biblio/6320539}, journal = {Aviation, Space and Environmental Medicine; (USA)},
issn = {0095-6562},
number = ,
volume = 61,
place = {United States},
year = {Sat Sep 01 00:00:00 EDT 1990},
month = {Sat Sep 01 00:00:00 EDT 1990}
}