Transdermal absorption of radioprotectors in the rat using permeation-enhancing vehicles

Journal Article · Thu Nov 01 00:00:00 EST 1990 · Radiation Research; (USA)

DOI:https://doi.org/10.2307/3577866· OSTI ID:6320158

Lamperti, A; Ziskin, M C; Bergey, E; Gorlowski, J; Sodicoff, M ^[1]

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1. Temple Univ. School of Medicine, Philadelphia, PA (USA)

Topical radioprotection of rat skin with WR-2721 has not been effective presumably because the drug does not cross the stratum corneum to reach the epidermis and dermis. Earlier, we showed in the mouse that WR-2721 and cysteine dissolved in permeation-enhancing vehicles passed through the skin more readily than when in water. However, the most effective vehicles in the mouse were not necessarily as effective in the rat. Here we report that the most effective transport vehicles in the rat were (1) water with WR-2721, (2) water and dimethylformamide (DMF) with cysteine, and (3) water and DMF with prostaglandin E2 (PGE2). Pretreatment of the skin with dimethylsulfoxide (DMSO) further improved the transfer of the radioprotectors across the skin in most cases. After pretreatment with DMSO, the most effective vehicles were (1) water for WR-2721, (2) water and methyl-2-pyrrolidone (M-2-P) for cysteine, and (3) DMF for PGE2.

• OSTI ID: 6320158
• Journal Information: Radiation Research; (USA), Vol. 124:2; ISSN 0033-7587
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
RADIOPROTECTIVE SUBSTANCES
SKIN ABSORPTION
AMIDES
CYSTEINE
DMSO
PROSTAGLANDINS
RATS
WATER
ABSORPTION
AMINO ACIDS
ANIMALS
CARBOXYLIC ACIDS
DRUGS
HYDROGEN COMPOUNDS
MAMMALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXYGEN COMPOUNDS
RODENTS
SULFOXIDES
THIOLS
UPTAKE
VERTEBRATES
560152* - Radiation Effects on Animals- Animals