Comparative effects of N,N-disubstituted dithiocarbamates and dimercaptosuccinate on mobilization of methylmercury in mice

Journal Article · Sun Jul 01 00:00:00 EDT 1984 · Res. Commun. Chem. Pathol. Pharmacol.; (United States)

OSTI ID:6300872

Gale, G R; Atkins, L M; Smith, A B; Walker, Jr, E M; Jones, M M

Diethyldithiocarbamate (DDTC) and five of its N,N-disubstituted analogs were compared with dimercaptosuccinate (DMSA) for effectiveness in mobilizing and promoting excretion of methylmercury (MeHg) following administration of a sublethal dose of MeHg labeled with Me203Hg. The previously reported effectiveness of DMSA was confirmed. Of the dithiocarbamates assessed, only di(carboxymethyl)-dithiocarbamate (DCDC) was active in mobilizing MeHg, and its activity on a molar dose basis was less than that of DMSA. The disparate structural requirements of dithiocarbamates as antagonists of MeHg and of cadmium were discussed.

• Research Organization: Veterans Administration Medical Center, Charleston, SC
• OSTI ID: 6300872
• Journal Information: Res. Commun. Chem. Pathol. Pharmacol.; (United States), Vol. 45:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHELATING AGENTS
BIOLOGICAL EFFECTS
METHYLMERCURY
EXCRETION
COMPARATIVE EVALUATIONS
MICE
ANIMALS
CLEARANCE
MAMMALS
MERCURY COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)