Microwave-induced post-exposure hyperthermia: Involvement of endogenous opioids and serotonin
Acute exposure to pulsed microwaves (2450 MHz, 1 mW/ cm/sup 2/, SAR 0.6 W/kg, 2-..mu..s pulses, 500 pulses/s) induces a transient post-exposure hyperthermia in the rat. The hyperthermia was attenuated by treatment with either the narcotic antagonist naltrexone or one of the serotonin antagonists cinanserin, cyproheptadine, or metergoline. It was not affected, however, by treatment with the peripheral serotonin antagonist xylamidine nor the dopamine antagonist haloperidol. It thus appears that both endogenous opioids and central serotonin are involved. It is proposed that pulsed microwaves activate endogenous opioid systems, and that they in turn activate a serotonergic mechanism that induces the rise in body temperature.
- Research Organization:
- Departments of Pharmacology, Psychiatry, and Behavioral Sciences, and the Center for Bioengineering, University of Washington School of Medicine, Seattle, WA 98195
- OSTI ID:
- 6300284
- Journal Information:
- IEEE Trans. Microwave Theory Tech.; (United States), Vol. MTT-32:8
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effects of opioid peptides on thermoregulation
Naltrexone-sensitive analgesia following exposure of mice to 2450-MHz radiofrequency radiation (RFR)
Related Subjects
MICROWAVE RADIATION
BIOLOGICAL EFFECTS
DOPAMINE
GHZ RANGE 01-100
HYPERTHERMIA
NARCOTICS
NEUROREGULATORS
RESPONSE MODIFYING FACTORS
SEROTONIN
SYNERGISM
TEMPERATURE EFFECTS
AMINES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BODY TEMPERATURE
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
ELECTROMAGNETIC RADIATION
FREQUENCY RANGE
GHZ RANGE
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHENOLS
POLYPHENOLS
PYRROLES
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
SYMPATHOMIMETICS
TRYPTAMINES
560400* - Other Environmental Pollutant Effects