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Title: Radiotherapy alone in breast cancer. I. Analysis of tumor parameters, tumor dose and local control: the experience of the Gustave-Roussy Institute and the Princess Margaret Hospital

Abstract

This retrospective study involved 463 breast cancer patients treated by radiotherapy alone at the Princess Margaret Hospital and at the Institut Gustave-Roussy. These patients either had operable tumors, but were unfit for general anesthesia, or had inoperable tumors due to local contraindications to surgery. Results were analyzed according to tumor response, local recurrence rate, tumor size, tumor fixation, nodal fixation and tumor dose. Conventional statistical analysis of local control showed two significant factors: tumor dose and tumor size. Multivariate analysis permitted to define an ''individual risk'' (IR) of local recurrence according to three independent factors: tumor size, tumor fixation, and nodal fixation. It was shown that the IR was a good prognostic factor for local control. Increase in tumor dose gave a similar effect in the local recurrence relative risk for all the IR groups. According to the slope of the dose-effect curve, it was deduced that a dose increase of 15 Gy can decrease the relative risk of local recurrence 2-fold. In fact, it was shown that tumor dose was the most significant independent factor on local control, able to produce up to a 10-fold increase compared to 2-fold decrease for tumor size. If the IR of local recurrencemore » is known, a theoretical predictive value on local control, taking into account the tumor dose, can be determined according to the present data.« less

Authors:
; ; ; ;
Publication Date:
Research Org.:
Institut Gustave-Roussy, Villejuif, France
OSTI Identifier:
6293024
Resource Type:
Journal Article
Journal Name:
Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Additional Journal Information:
Journal Volume: 10
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; NEOPLASMS; RADIATION DOSES; RADIOTHERAPY; EVALUATION; LYMPH NODES; MAMMARY GLANDS; METASTASES; MULTIVARIATE ANALYSIS; PATIENTS; BODY; DISEASES; DOSES; GLANDS; LYMPHATIC SYSTEM; MATHEMATICS; MEDICINE; NUCLEAR MEDICINE; ORGANS; RADIOLOGY; STATISTICS; THERAPY; 560151* - Radiation Effects on Animals- Man; 550603 - Medicine- External Radiation in Therapy- (1980-)

Citation Formats

Arriagada, R, Mouriesse, H, Sarrazin, D, Clark, R M, and Deboer, G. Radiotherapy alone in breast cancer. I. Analysis of tumor parameters, tumor dose and local control: the experience of the Gustave-Roussy Institute and the Princess Margaret Hospital. United States: N. p., 1985. Web. doi:10.1016/0360-3016(85)90027-6.
Arriagada, R, Mouriesse, H, Sarrazin, D, Clark, R M, & Deboer, G. Radiotherapy alone in breast cancer. I. Analysis of tumor parameters, tumor dose and local control: the experience of the Gustave-Roussy Institute and the Princess Margaret Hospital. United States. https://doi.org/10.1016/0360-3016(85)90027-6
Arriagada, R, Mouriesse, H, Sarrazin, D, Clark, R M, and Deboer, G. 1985. "Radiotherapy alone in breast cancer. I. Analysis of tumor parameters, tumor dose and local control: the experience of the Gustave-Roussy Institute and the Princess Margaret Hospital". United States. https://doi.org/10.1016/0360-3016(85)90027-6.
@article{osti_6293024,
title = {Radiotherapy alone in breast cancer. I. Analysis of tumor parameters, tumor dose and local control: the experience of the Gustave-Roussy Institute and the Princess Margaret Hospital},
author = {Arriagada, R and Mouriesse, H and Sarrazin, D and Clark, R M and Deboer, G},
abstractNote = {This retrospective study involved 463 breast cancer patients treated by radiotherapy alone at the Princess Margaret Hospital and at the Institut Gustave-Roussy. These patients either had operable tumors, but were unfit for general anesthesia, or had inoperable tumors due to local contraindications to surgery. Results were analyzed according to tumor response, local recurrence rate, tumor size, tumor fixation, nodal fixation and tumor dose. Conventional statistical analysis of local control showed two significant factors: tumor dose and tumor size. Multivariate analysis permitted to define an ''individual risk'' (IR) of local recurrence according to three independent factors: tumor size, tumor fixation, and nodal fixation. It was shown that the IR was a good prognostic factor for local control. Increase in tumor dose gave a similar effect in the local recurrence relative risk for all the IR groups. According to the slope of the dose-effect curve, it was deduced that a dose increase of 15 Gy can decrease the relative risk of local recurrence 2-fold. In fact, it was shown that tumor dose was the most significant independent factor on local control, able to produce up to a 10-fold increase compared to 2-fold decrease for tumor size. If the IR of local recurrence is known, a theoretical predictive value on local control, taking into account the tumor dose, can be determined according to the present data.},
doi = {10.1016/0360-3016(85)90027-6},
url = {https://www.osti.gov/biblio/6293024}, journal = {Int. J. Radiat. Oncol., Biol. Phys.; (United States)},
number = ,
volume = 10,
place = {United States},
year = {Tue Oct 01 00:00:00 EDT 1985},
month = {Tue Oct 01 00:00:00 EDT 1985}
}