Gamma-Aminobutyric acid and benzodiazepine receptors in the kindling model of epilepsy: a quantitative radiohistochemical study
Quantitative radiohistochemistry was utilized to study alterations of gamma-aminobutyric acid (GABA) and benzodiazepine receptors in the kindling model of epilepsy. The radioligands used for GABA and benzodiazepine receptors were (TH) muscimol and (TH)flunitrazepam, respectively. GABA receptor binding was increased by 22% in fascia dentata of the hippocampal formation but not in neocortex or substantia nigra of kindled rats. Within fascia dentata, GABA receptor binding was increased to an equivalent extent in stratum granulosum and throughout stratum moleculare; no increase was found in dentate hilus or stratum lacunosummoleculare or stratum radiatum of CA1. The increased binding was present at 24 hr but not at 28 days after the last kindled seizure. The direction, anatomic distribution, and time course of the increased GABA receptor binding were paralleled by increased benzodiazepine receptor binding. The anatomic distribution of the increased GABA receptor binding is consistent with a localization to somata and dendritic trees of dentate granule cells. The authors suggest that increased GABA and benzodiazepine receptor binding may contribute to enhanced inhibition of dentate granule cells demonstrated electrophysiologically in kindled animals.
- Research Organization:
- Duke Univ. Medical Center, Durham, NC
- OSTI ID:
- 6290952
- Journal Information:
- J. Neurosci.; (United States), Vol. 10
- Country of Publication:
- United States
- Language:
- English
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AMINOBUTYRIC ACID
TISSUE DISTRIBUTION
BRAIN
AUTORADIOGRAPHY
CYTOCHEMISTRY
TRANQUILIZERS
TRITIUM COMPOUNDS
EPILEPSY
RATS
RECEPTORS
AMINO ACIDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMISTRY
BODY
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
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DISEASES
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DRUGS
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ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PSYCHOTROPIC DRUGS
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550301* - Cytology- Tracer Techniques