Effect of an imidazobenzodiazepine, Ro15-4513, on the incoordination and hypothermia produced by ethanol and pentobarbital

Journal Article · Mon Aug 03 00:00:00 EDT 1987 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(87)90415-2· OSTI ID:6290840

Hoffman, P L; Tabakoff, B; Szabo, G; Suzdak, P D; Paul, S M

The imidazobenzodiazepine, Ro15-4513, which is a partial inverse agonist at brain benzodiazepine receptors, reversed the incoordinating effect of ethanol in mice, as measured on an accelerating Rotarod. This effect was blocked by benzodiazepine receptor antagonists. In contrast, Ro15-4513 had no effect on ethanol-induced hypothermia in mice. However, Ro15-4513 reversed the hypothermic effect of pentobarbital, and, at higher dose, also reversed the incoordinating effect of pentobarbital in mice. The data support the hypothesis that certain of the pharmacological effects of ethanol are mediated by actions at the GABA-benzodiazepine receptor-coupled chloride channel. 35 references, 2 figures.

• Research Organization: National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD
• OSTI ID: 6290840
• Journal Information: Life Sci.; (United States), Vol. 41:5
• Country of Publication: United States
• Language: English

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