Fetal lead exposure: antenatal factors

Conference · Tue Oct 01 00:00:00 EDT 1985 · Environ. Res.; (United States)

OSTI ID:6284513

Ernhart, C B; Wolf, A W; Sokol, R J; Brittenham, G M; Erhard, P

It was hypothesized that maternal blood lead level at delivery and cord blood lead level of the neonate would be affected by maternal use of alcohol, history of alcohol abuse, and smoking. The possibility that iron status, as reflected in maternal serum ferritin, would be related to lead level was also explored. The maternal history of alcohol abuse was unrelated to lead level in 208 samples of maternal blood and 178 samples of cord blood. However, alcohol use during pregnancy was related in a dose-response fashion to maternal and to cord blood lead level. This effect was significant with and without control of maternal smoking. The effect of maternal smoking and serum thiocyanate on maternal and cord blood lead level were also highly significant with and without control of the maternal drinking variable. Serum ferritin was marginally related to lead level for white women and for black infants, but tests of the dichotomized maternal ferritin variable did not yield a significant linkage with maternal or cord blood lead level. The results further support recommendations that women abstain from alcohol consumption and cigarette smoking in pregnancy.

• Research Organization: Case Western Reserve Univ., Cleveland, OH
• OSTI ID: 6284513
• Journal Information: Environ. Res.; (United States), Vol. 38:1; Conference: 2. international conference on prospective studies of lead, Cincinnati, OH, USA, 9-11 Apr 1984
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LEAD
BIOLOGICAL ACCUMULATION
ENVIRONMENTAL EXPOSURE PATHWAY
HEALTH HAZARDS
PRENATAL EXPOSURE
LIFE STYLES
RESPONSE MODIFYING FACTORS
BLOOD
DOSE-RESPONSE RELATIONSHIPS
ETHANOL
FERRITIN
IRON
NEONATES
PREGNANCY
TOBACCO SMOKES
WOMEN
AEROSOLS
ALCOHOLS
ANIMALS
BIOLOGICAL MATERIALS
BODY FLUIDS
COLLOIDS
COMPLEXES
DISPERSIONS
ELEMENTS
FEMALES
HAZARDS
HYDROXY COMPOUNDS
IRON COMPLEXES
MAMMALS
MAN
MATERIALS
METALLOPROTEINS
METALS
ORGANIC COMPOUNDS
PRIMATES
PROTEINS
RESIDUES
SMOKES
SOLS
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENTS
VERTEBRATES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)