Dose-response studies with ethylene dibromide. [Hydra oligactis]
This study represents the first of a series of Descriptive-Reproductive-Toxicology Studies currently underway in the authors laboratory. Ethylene Dibromide (EDB) is suspected of causing infertility (especially in males), carcinogenesis, mutagenesis, and possibly teratogenesis. Coupling the suspected undesirable effects of EDB exposure with the fact that the chemical has broad utility (soil fumigant, fruit and grain fumigant, gasoline additive, etc.), EDB is an important agricultural and industrial toxin. In this study Hydra oligactis are exposed to EDB in an attempt to determine the acute toxicity of the chemical. Since Hydra is organized at the tissue level only, the toxin can be applied as a component of an artificial pond water (APW) medium. The EDB stock solution is 19:1 Acetone (emulsifier): EDB. Direct dilutions are made and exposures are continuous. The medium is exchanged daily after feeding. The LC50 at 48 hours incubation with EDb is 70 mgL . Compared to the LC50's for two common commercial PCB mixtures, Aroclors 1254 and 1016, EDb is shown to be a highly toxic chemical. The respective LC50's for the PCB's are 20 mgL (Aroclor 1254) and 5 mgL (Aroclor 1016) at 72 hrs. Sublethal EDB toxicity is currently being studied.
- Research Organization:
- Tennessee State Univ., Nashville
- OSTI ID:
- 6279336
- Journal Information:
- J. Tenn. Acad. Sci.; (United States), Vol. 62:2
- Country of Publication:
- United States
- Language:
- English
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