Effect of hypocapnia on local cerebral glucose utilization in rats

Journal Article · Wed Mar 01 00:00:00 EST 1989 · Anesthesiology; (United States)

DOI:https://doi.org/10.1097/00000542-198903000-00024· OSTI ID:6279319

Samra, S K; Turk, P; Arens, J F

The effect of hypocapnia on regional cerebral glucose utilization (L-CMRg) was studied in 14 Sprague Dawley rats. After cannulation of femoral vessels, halothane was discontinued and anesthesia was maintained with 70% N/sub 2/O in oxygen. The animals' lungs were mechanically ventilated to achieve normocapnia (PaCO/sub 2/ = 40 +/- 2 mmHg) in group A or hypocapnia (PaCO/sub 2/ = 25 +/- 2 mmHg) in group B. L-CMRg was measured by the /sup 14/C-2-deoxyglucose autoradiographic method. Twenty-six anatomically discrete structures representing cortical, subcortical, limbic, and brainstem areas were studied. In hypocapnic animals, mean values for L-CMRg were higher in 25 out of 26 structures studied. The increase in L-CMRg was heterogenous. The structures that had higher L-CMRg during normocapnia showed the greatest increase in L-CMRg. When the two groups were compared using a profile analysis, in six regions (lateral and ventral thalamus, inferior colliculus, lateral habenulla, medial geniculate body, and auditory cortex), a value of P less than 0.05 was obtained.

• Research Organization: Univ. of Texas Medical Branch, Galveston (USA)
• OSTI ID: 6279319
• Journal Information: Anesthesiology; (United States), Vol. 70:3
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARBON DIOXIDE
BIOLOGICAL EFFECTS
GLUCOSE
METABOLISM
AUTORADIOGRAPHY
BRAIN
CARBON 14 COMPOUNDS
NITROUS OXIDE
OXYGEN
RATS
ALDEHYDES
ANIMALS
BODY
CARBOHYDRATES
CARBON COMPOUNDS
CARBON OXIDES
CENTRAL NERVOUS SYSTEM
CHALCOGENIDES
ELEMENTS
HEXOSES
LABELLED COMPOUNDS
MAMMALS
MONOSACCHARIDES
NERVOUS SYSTEM
NITROGEN COMPOUNDS
NITROGEN OXIDES
NONMETALS
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
RODENTS
SACCHARIDES
VERTEBRATES
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