Mechanisms of microwave-induced blood-brain barrier alterations. Final report 1 Apr 1978-31 Aug 1980

Technical Report · Mon Sep 01 00:00:00 EDT 1980

OSTI ID:6279210

Lin, J C

This investigation was designed to study the mechanisms of interaction between microwaves and the blood-brain barrier and was aimed at correlating changes of blood-brain barrier permeability with the quantity and distribution of absorbed microwave energy inside the brain of adult Wistar rats under sodium pentobarbital anesthesia. Through use of thermographic methods and a direct-contact applicator at the animal's head, the pattern of absorbed microwave energy was determined. Indwelling catheters were placed in the femoral vein. Evans blue in isotonic saline were used as a visual indicator of barrier permeation. Irradiation with pulsed 2450-MHz microwaves for 20 min at average power densities of 0.5 to 2600 mW/squared, which resulted in average specific absorption rates (SARs) of 0.04 to 200 mW/g in the brain, did not produce staining, except in regions that normally are highly permeable. When the incident power density was increased to 3000 mW/squared (SAR of 240 mW/g), extravasation of Evans blue could be seen in the cortex, hippocampus and midbrain.

• Research Organization: Wayne State Univ., Detroit, MI (USA). Dept. of Electrical and Computer Engineering
• DOE Contract Number: N00014-78-C-0353
• OSTI ID: 6279210
• Report Number(s): AD-A-091047
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BRAIN
PERMEABILITY
MICROWAVE RADIATION
BIOLOGICAL RADIATION EFFECTS
BLOOD
DOSE-RESPONSE RELATIONSHIPS
HISTOLOGY
INTERACTIONS
IRRADIATION
RADIATION DOSES
RATS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CENTRAL NERVOUS SYSTEM
DOSES
ELECTROMAGNETIC RADIATION
MAMMALS
MATERIALS
NERVOUS SYSTEM
ORGANS
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
560400* - Other Environmental Pollutant Effects