Changes in lymphocyte subsets and macrophage functions from high, short-term dietary ethanol in C57/BL6 mice
Chronic administration of a diet containing 7% ethanol (36% of total calories) for 8 days to male C57/BL6 mice resulted in significant changes in functioning of macrophages. Peritoneal exudate macrophages from the ethanol-fed mice released more tumor cell cytotoxic materials upon culturing in vitro than cells from controls. However, peritoneal exudate cells continued to respond to exogenous beta carotene in vitro to produce additional cytotoxic materials. Phagocytosis of sheep red blood cells in vitro was suppressed in cells from ethanol treated mice. The number of splenic lymphocytes of various subsets was significantly changed by the ethanol exposure. Total T cells and T suppressor cells were lower, with a significant decrease in B cells containing IgM on their surface. The percentage of spleen cells showing markers for macrophage functions and their activation were significantly reduced. It is concluded that short-term chronic consumption of dietary ethanol, which was sufficient to produce physical dependence, results in significant alterations in lymphocyte subtypes and suppression of some macrophage functions.
- Research Organization:
- Univ. of Arizona, Tucson (USA)
- OSTI ID:
- 6277614
- Journal Information:
- Life Sci.; (United States), Vol. 43:10
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ETHANOL
BIOLOGICAL EFFECTS
LYMPHOCYTES
CELL PROLIFERATION
MACROPHAGES
BIOLOGICAL FUNCTIONS
CELL CULTURES
CHRONIC EXPOSURE
DIET
ERYTHROCYTES
PHAGOCYTOSIS
ALCOHOLS
ANIMAL CELLS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
FUNCTIONS
HYDROXY COMPOUNDS
LEUKOCYTES
MATERIALS
ORGANIC COMPOUNDS
PHAGOCYTES
SOMATIC CELLS
560300* - Chemicals Metabolism & Toxicology