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Title: Maximum recovery potential of human tumor cells may predict clinical outcome in radiotherapy

Abstract

We studied inherent radiosensitivity/resistance (D0), ability to accumulate sublethal damage (n) and repair of potentially lethal damage (PLDR) in established human tumor cell lines as well as early passage human tumor cell lines derived from patients with known outcome following radiotherapy. Survival 24 hrs after treatment of human tumor cells with X rays in plateau phase cultures is a function of initial damage (D0, n), as well as recovery over 24 hrs (PLDR). A surviving fraction greater than .1 24 hrs following treatment with 7 Gy in plateau phase cultures is associated with tumor cell types (melanoma, osteosarcoma) with a high probability of radiotherapy failure or tumor cells derived from patients who actually failed radiotherapy. Therefore, total cellular recovery following radiation may be an important determinant of radiocurability. Accurate assays of radiotherapy outcome may need to account for all these radiobiological parameters.

Authors:
;
Publication Date:
Research Org.:
Michael Reese/Univ. of Chicago, IL
OSTI Identifier:
6275553
Resource Type:
Journal Article
Journal Name:
Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Additional Journal Information:
Journal Volume: 5
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; RADIOTHERAPY; RADIOBIOLOGY; TUMOR CELLS; BIOLOGICAL REPAIR; RADIOSENSITIVITY; BIOLOGICAL RECOVERY; DNA REPAIR; MELANOMAS; NEOPLASMS; OSTEOSARCOMAS; PATIENTS; RADIATION INJURIES; SURVIVAL CURVES; X RADIATION; ANIMAL CELLS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BIOLOGY; DISEASES; ELECTROMAGNETIC RADIATION; INJURIES; IONIZING RADIATIONS; MEDICINE; NUCLEAR MEDICINE; RADIATION EFFECTS; RADIATIONS; RADIOLOGY; RECOVERY; REPAIR; SARCOMAS; SKELETAL DISEASES; THERAPY; 550603* - Medicine- External Radiation in Therapy- (1980-); 560120 - Radiation Effects on Biochemicals, Cells, & Tissue Culture

Citation Formats

Weichselbaum, R R, and Beckett, M. Maximum recovery potential of human tumor cells may predict clinical outcome in radiotherapy. United States: N. p., 1987. Web. doi:10.1016/0360-3016(87)90289-6.
Weichselbaum, R R, & Beckett, M. Maximum recovery potential of human tumor cells may predict clinical outcome in radiotherapy. United States. https://doi.org/10.1016/0360-3016(87)90289-6
Weichselbaum, R R, and Beckett, M. 1987. "Maximum recovery potential of human tumor cells may predict clinical outcome in radiotherapy". United States. https://doi.org/10.1016/0360-3016(87)90289-6.
@article{osti_6275553,
title = {Maximum recovery potential of human tumor cells may predict clinical outcome in radiotherapy},
author = {Weichselbaum, R R and Beckett, M},
abstractNote = {We studied inherent radiosensitivity/resistance (D0), ability to accumulate sublethal damage (n) and repair of potentially lethal damage (PLDR) in established human tumor cell lines as well as early passage human tumor cell lines derived from patients with known outcome following radiotherapy. Survival 24 hrs after treatment of human tumor cells with X rays in plateau phase cultures is a function of initial damage (D0, n), as well as recovery over 24 hrs (PLDR). A surviving fraction greater than .1 24 hrs following treatment with 7 Gy in plateau phase cultures is associated with tumor cell types (melanoma, osteosarcoma) with a high probability of radiotherapy failure or tumor cells derived from patients who actually failed radiotherapy. Therefore, total cellular recovery following radiation may be an important determinant of radiocurability. Accurate assays of radiotherapy outcome may need to account for all these radiobiological parameters.},
doi = {10.1016/0360-3016(87)90289-6},
url = {https://www.osti.gov/biblio/6275553}, journal = {Int. J. Radiat. Oncol., Biol. Phys.; (United States)},
number = ,
volume = 5,
place = {United States},
year = {Fri May 01 00:00:00 EDT 1987},
month = {Fri May 01 00:00:00 EDT 1987}
}