Chromato-mass spectrometric investigation of the quality of the starting materials, intermediate, and final products of the synthesis of N-(. cap alpha. -bromoisovaleryl)urea

Journal Article · Mon Jun 01 00:00:00 EDT 1987 · Pharmaceut. Chem. J.; (United States)

OSTI ID:6272529

Evtushenko, N S; Klyuev, N A

The authors develop new procedures for the analysis of the quality of the starting materials and main intermediate products of the synthesis of N-(alpha-bromoisovaleryl)urea using a complex of physicochemical methods of analysis -- gas-liquid chromatography and chromato-mass spectrometry. The chromatographic peaks were identified using the criteria of the mass numbers of the molecular ions M/sup +/, the specific ratios of isotopes of the halogens present in M/sup +/ and fragment ions of the test compound, as well as characteristic directions of fragmentation of M/sup +/ associated with the structure of the substances.

• Research Organization: State Scientific Research Institute for the Standardization and Testing of Drugs, Moscow (USSR)
• OSTI ID: 6272529
• Journal Information: Pharmaceut. Chem. J.; (United States), Vol. 20:8; Other Information: Translated from Khimiko-Farmatsevticheski Zhurnal; 20: No. 8, 1004-1009(Aug 1986)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
74 ATOMIC AND MOLECULAR PHYSICS
AMIDES
BIOLOGICAL EFFECTS
CHROMATOGRAPHY
MASS SPECTRA
SYNTHESIS
HYPNOTICS AND SEDATIVES
MATERIALS TESTING
ORGANIC BROMINE COMPOUNDS
BROMINE ISOTOPES
DISSOCIATION
ELECTRON BEAMS
ELECTRON-MOLECULE COLLISIONS
EV RANGE 10-100
IONIZATION
ISOTOPE RATIO
MOLECULAR IONS
VALERIC ACID
BEAMS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHARGED PARTICLES
COLLISIONS
DRUGS
ELECTRON COLLISIONS
ENERGY RANGE
EV RANGE
IONS
ISOTOPES
LEPTON BEAMS
MOLECULE COLLISIONS
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PARTICLE BEAMS
SEPARATION PROCESSES
SPECTRA
TESTING
550200* - Biochemistry
640304 - Atomic
Molecular & Chemical Physics- Collision Phenomena