Dynamic properties of blood flow and leukocyte mobilization in infected flaps

Journal Article · Thu Nov 01 00:00:00 EST 1990 · World Journal of Surgery; (USA)

DOI:https://doi.org/10.1007/BF01670526· OSTI ID:6271873

Feng, L J; Price, D C; Mathes, S J; Hohn, D ^[1]

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1. Univ. of California, San Francisco (USA)

Two aspects of the inflammatory response to infection--blood flow alteration and leukocyte mobilization--are investigated in the canine model. The elevation of paired musculocutaneous (MC) and random pattern (RP) flaps allowed comparison of healing flaps with significant differences in blood flow (lower in random pattern flaps) and resistance to infection (greater in musculocutaneous flaps). Blood flow changes as determined by radioactive xenon washout were compared in normal skin and distal flap skin both after elevation and following bacterial inoculation. Simultaneous use of In-111 labeled leukocytes allowed determination of leukocyte mobilization and subsequent localization in response to flap infection. Blood flow significantly improved in the musculocutaneous flap in response to infection. Although total leukocyte mobilization in the random pattern flap was greater, the leukocytes in the musculocutaneous flap were localized around the site of bacterial inoculation within the dermis. Differences in the dynamic blood flow and leukocyte mobilization may, in part, explain the greater reliability of musculocutaneous flaps when transposed in the presence of infection.

• OSTI ID: 6271873
• Journal Information: World Journal of Surgery; (USA), Vol. 14:6, Issue 6; ISSN 0364-2313
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
LEUKOCYTES
BIOLOGICAL LOCALIZATION
SKIN
BLOOD FLOW
WOUNDS
HEALING
BACTERIAL DISEASES
BIOLOGICAL MODELS
DOGS
GRAFTS
INDIUM 111
TRACER TECHNIQUES
XENON ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL RECOVERY
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
INDIUM ISOTOPES
INFECTIOUS DISEASES
INJURIES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
RECOVERY
TRANSPLANTS
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques