Relationship of oxygen dose to angiogenesis induction in irradiated tissue

Journal Article · Thu Nov 01 00:00:00 EST 1990 · American Journal of Surgery; (USA)

DOI:https://doi.org/10.1016/S0002-9610(05)81019-0· OSTI ID:6270679

Marx, R E; Ehler, W J; Tayapongsak, P; Pierce, L W ^[1]

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1. Univ. of Miami School of Medicine/Jackson Memorial Medical Center, FL (USA)

This study was accomplished in an irradiated rabbit model to assess the angiogenic properties of normobaric oxygen and hyperbaric oxygen as compared with air-breathing controls. Results indicated that normobaric oxygen had no angiogenic properties above normal revascularization of irradiated tissue than did air-breathing controls (p = 0.89). Hyperbaric oxygen demonstrated an eight- to ninefold increased vascular density over both normobaric oxygen and air-breathing controls (p = 0.001). Irradiated tissue develops a hypovascular-hypocellular-hypoxic tissue that does not revascularize spontaneously. Results failed to demonstrate an angiogenic effect of normobaric oxygen. It is suggested that oxygen in this sense is a drug requiring hyperbaric pressures to generate therapeutic effects on chronically hypovascular irradiated tissue.

• OSTI ID: 6270679
• Journal Information: American Journal of Surgery; (USA), Vol. 160:5; ISSN 0002-9610
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
OXYGEN
RADIOSENSITIVITY EFFECTS
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560152* - Radiation Effects on Animals- Animals