Role of chest irradiation in limited small cell carcinoma of the lung treated with combination chemotherapy

Looper, J D; Hornback, N B

doi:10.1016/0360-3016(84)90262-1

Title: Role of chest irradiation in limited small cell carcinoma of the lung treated with combination chemotherapy

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Abstract

Between October 1974 and December 1980, 123 patients with limited small cell carcinoma were treated in the Indiana University Medical Center Department of Radiation Oncology. Of these, 115 were treated with preplanned combined modality therapy using irradiation and polychemotherapy (Adriamycin, Cytoxan and Oncovin). All patients received whole brain prophylactic irradiation and were followed a minimum of 2 years. Sixty-six patients were given chest irradiation with all but two receiving 3500-4000 rad while 49 did not receive this treatment. Sixty-five percent of those patients receiving chest irradiation had a complete response to therapy, as opposed to 33% who did not. This study demonstrates an increase response rate, median survival, and overall survival in patients receiving chest irradiation. The high rate of relapse in the chest suggests the need for more effective control of the primary. This may be accomplished by increasing the dose of chest irradiation or surgical removal when feasible.

Authors:: Looper, J D; Hornback, N B

Publication Date:: Mon Oct 01 00:00:00 EDT 1984

Research Org.:: Indiana Univ. School of Medicine, Indianapolis

OSTI Identifier:: 6270095

Resource Type:: Journal Article

Journal Name:: Int. J. Radiat. Oncol., Biol. Phys.; (United States)

Additional Journal Information:: Journal Volume: 10:10

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; CHEMOTHERAPY; RADIOTHERAPY; EVALUATION; BRAIN; CHEST; DOXORUBICIN; LUNGS; ONCOVIN; PARTIAL BODY IRRADIATION; PATIENTS; ALKALOIDS; ANTI-INFECTIVE AGENTS; ANTIBIOTICS; ANTIMITOTIC DRUGS; ANTINEOPLASTIC DRUGS; BODY; BODY AREAS; CENTRAL NERVOUS SYSTEM; DISEASES; DRUGS; EXTERNAL IRRADIATION; IRRADIATION; MEDICINE; NEOPLASMS; NERVOUS SYSTEM; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; ORGANS; RADIOLOGY; RESPIRATORY SYSTEM; THERAPY; 550603* - Medicine- External Radiation in Therapy- (1980-)

Citation Formats


                    Looper, J D, and Hornback, N B. Role of chest irradiation in limited small cell carcinoma of the lung treated with combination chemotherapy.  United States: N. p., 1984. 
        Web.  doi:10.1016/0360-3016(84)90262-1.

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                    Looper, J D, & Hornback, N B. Role of chest irradiation in limited small cell carcinoma of the lung treated with combination chemotherapy.  United States.  https://doi.org/10.1016/0360-3016(84)90262-1

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                    Looper, J D, and Hornback, N B. 1984.  
        "Role of chest irradiation in limited small cell carcinoma of the lung treated with combination chemotherapy".  United States.  https://doi.org/10.1016/0360-3016(84)90262-1.

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@article{osti_6270095,

  title        = {Role of chest irradiation in limited small cell carcinoma of the lung treated with combination chemotherapy},

  author       = {Looper, J D and Hornback, N B},

  abstractNote = {Between October 1974 and December 1980, 123 patients with limited small cell carcinoma were treated in the Indiana University Medical Center Department of Radiation Oncology. Of these, 115 were treated with preplanned combined modality therapy using irradiation and polychemotherapy (Adriamycin, Cytoxan and Oncovin). All patients received whole brain prophylactic irradiation and were followed a minimum of 2 years. Sixty-six patients were given chest irradiation with all but two receiving 3500-4000 rad while 49 did not receive this treatment. Sixty-five percent of those patients receiving chest irradiation had a complete response to therapy, as opposed to 33% who did not. This study demonstrates an increase response rate, median survival, and overall survival in patients receiving chest irradiation. The high rate of relapse in the chest suggests the need for more effective control of the primary. This may be accomplished by increasing the dose of chest irradiation or surgical removal when feasible.},

  doi          = {10.1016/0360-3016(84)90262-1},

  url          = {https://www.osti.gov/biblio/6270095},
  journal      = {Int. J. Radiat. Oncol., Biol. Phys.; (United States)},
number       = ,

  volume       = 10:10,

  place        = {United States},

  year         = {Mon Oct 01 00:00:00 EDT 1984},

  month        = {Mon Oct 01 00:00:00 EDT 1984}

}

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