Pathogenesis and modification of cadmium-induced lung injury in mice
The effects of hyperoxia on Cd-damaged mouse lungs were studied to determine if there was potentiation of the injury by O/sub 2/. Female Balb/c mice were exposed to aerosols of 0.65% CdCl/sub 2/ for one hour by the nose-only method while control animals were exposed to water aerosols. Immediately after, some animals were placed in 70 to 80% O/sub 2/ for days, while others were left in room air. Cd exposed animals had significantly increased levels of hydroxyproline/lung, indicative of increased collagen secretion and hence fibrosis. The Cd + O/sub 2/ exposed animals had even higher levels showing the synergistic effects of O/sub 2/. Experiments on the effects of prednisolone and X radiation in modifying the Cd-induced injury were also done but neither showed any alteration of the Cd-induced lesion. Pretreatment with 1 mg/kg of Cd i.p. for 4 days before Cd inhalation was also shown not to alter fibrosis. Investigations were made of the long term effects of Cd + O/sub 2/ on the fibrotic lesion. Mechanisms of the action of Cd, and a literature survey are included. The study provides an experimental model for the interactions of two inhalants, Cd and O/sub 2/, and elucidates the behavior of different cell populations following injury.
- OSTI ID:
- 6267715
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CADMIUM
BIOLOGICAL EFFECTS
OXYGEN
RESPONSE MODIFYING FACTORS
COMPARATIVE EVALUATIONS
INJURIES
LUNGS
MICE
SYNERGISM
ANIMALS
BODY
ELEMENTS
MAMMALS
METALS
NONMETALS
ORGANS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)