Hematopoiesis and aging. IV. Mass and distribution of erythroid marrow in aged mice
Aged mice are ''anemic,'' i.e., they have a lower hematocrit than young adult mice, but this appears to be a ''dilutional'' anemia; the red cell mass is normal. Other observations have supported the hypothesis that basal erythropoiesis does not change as mice grow old. In the present study, the percentage of injected VZFe found in the skeleton and spleen, VZFe distribution between various bones and bone groups, and the number of nucleated erythroid cells per humerus were studied and the total mass of erythroid precursors was calculated. There was no significant difference in any of these values between mice aged 3-27 months. The variability of VZFe distribution within various skeletal parts was no greater in aged than in young mice. Thus, these data further strengthen the case for normal basal rates of erythropoiesis in aged mice.
- Research Organization:
- Univ. of Pittsburgh School of Medicine, PA
- OSTI ID:
- 6258127
- Journal Information:
- Exp. Hematol.; (United States), Vol. 10
- Country of Publication:
- United States
- Language:
- English
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ERYTHROPOIESIS
AGE DEPENDENCE
IRON 59
TISSUE DISTRIBUTION
BONE MARROW
LIVER
MICE
SKELETON
SPLEEN
STEM CELLS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FORMATION
BODY
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
EVEN-ODD NUCLEI
GLANDS
HEMATOPOIETIC SYSTEM
INTERMEDIATE MASS NUCLEI
IRON ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ORGANS
RADIOISOTOPES
RODENTS
SOMATIC CELLS
TISSUES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics