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Title: Photocarcinogenesis by methoxypsoralen, neutral red, proflavine, and long UV radiation

Abstract

A study of the photosensitizing effects of 8-methoxypsoralen (MOP), neutral red (NR), and proflavine (PF) on the skin of female Swiss albino mice, strain 955, was carried out using fractionated exposure to long ultraviolet light (300-400 nm) and visible light (tungsten emission). The results (1) confirmed MOP photocarcinogenicity, (2) demonstrated that both NR and PF are photocarcinogens, and, further, (3) showed that the above UV light with 2.6% of fluence at 313 nm is a long-term carcinogenic agent even though the total dose of 313 nm was 100 times less than the minimal UV tumorigenic dose in mice. The tumors were mammary adenocarcinomas, carcinomas of skin appendages, carcino-mixo-sarcomas, lymphomas, and one case of thyroid adenocarcinoma. The implications of the above data regarding the controversy about oncogenic risks in photochemotherapy are discussed.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Univ. of Pavia, Italy
OSTI Identifier:
6254509
Resource Type:
Journal Article
Journal Name:
Cancer Detect. Prev.; (United States)
Additional Journal Information:
Journal Volume: 4
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; NEOPLASMS; RADIOINDUCTION; NEUTRAL RED; RADIOSENSITIVITY EFFECTS; PROFLAVINE; PSORALEN; ACRIDINES; CARCINOMAS; LYMPHOMAS; MICE; NEAR ULTRAVIOLET RADIATION; SARCOMAS; SKIN; VISIBLE RADIATION; AMINES; ANIMALS; ANTICOAGULANTS; AROMATICS; AZAARENES; AZINES; BODY; COUMARINS; DISEASES; DRUGS; ELECTROMAGNETIC RADIATION; FLAVINES; HEMATOLOGIC AGENTS; HETEROCYCLIC COMPOUNDS; INDICATORS; MAMMALS; MUTAGENS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; ORGANS; PYRAZINES; PYRIDINES; RADIATIONS; RODENTS; ULTRAVIOLET RADIATION; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Santamaria, L, Bianchi, A, Arnaboldi, A, Daffara, P, and Andreoni, L. Photocarcinogenesis by methoxypsoralen, neutral red, proflavine, and long UV radiation. United States: N. p., 1985. Web.
Santamaria, L, Bianchi, A, Arnaboldi, A, Daffara, P, & Andreoni, L. Photocarcinogenesis by methoxypsoralen, neutral red, proflavine, and long UV radiation. United States.
Santamaria, L, Bianchi, A, Arnaboldi, A, Daffara, P, and Andreoni, L. 1985. "Photocarcinogenesis by methoxypsoralen, neutral red, proflavine, and long UV radiation". United States.
@article{osti_6254509,
title = {Photocarcinogenesis by methoxypsoralen, neutral red, proflavine, and long UV radiation},
author = {Santamaria, L and Bianchi, A and Arnaboldi, A and Daffara, P and Andreoni, L},
abstractNote = {A study of the photosensitizing effects of 8-methoxypsoralen (MOP), neutral red (NR), and proflavine (PF) on the skin of female Swiss albino mice, strain 955, was carried out using fractionated exposure to long ultraviolet light (300-400 nm) and visible light (tungsten emission). The results (1) confirmed MOP photocarcinogenicity, (2) demonstrated that both NR and PF are photocarcinogens, and, further, (3) showed that the above UV light with 2.6% of fluence at 313 nm is a long-term carcinogenic agent even though the total dose of 313 nm was 100 times less than the minimal UV tumorigenic dose in mice. The tumors were mammary adenocarcinomas, carcinomas of skin appendages, carcino-mixo-sarcomas, lymphomas, and one case of thyroid adenocarcinoma. The implications of the above data regarding the controversy about oncogenic risks in photochemotherapy are discussed.},
doi = {},
url = {https://www.osti.gov/biblio/6254509}, journal = {Cancer Detect. Prev.; (United States)},
number = ,
volume = 4,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 1985},
month = {Tue Jan 01 00:00:00 EST 1985}
}