Combined effects of X rays, Ro 03-8799, and hyperthermia on growth, necrosis, and cell proliferation in a mouse tumor
A mouse adenocarcinoma was treated with 20 Gy X rays, hyperthermia (30 minutes at 43 degrees C), Ro-03-8799, or a combination of two or three of these agents. Combined treatments increase growth delay in the tumor and this was greatest with the combination of all three modalities. Extensive amounts of necrosis were observed after the combined treatments. This effect was most pronounced after treatment modalities including hyperthermia. On the other hand, the radiation-induced micronucleus formation was more enhanced by the sensitizer than by hyperthermia. After X irradiation and combined treatments with X rays a G2-block was observed in DNA-histograms. Tetraploid cells appeared in large amounts that started DNA synthesis followed by necrosis. From these tumors it was impossible to obtain regular DNA-histograms. Tumor regression is a combined result of reduced cell renewal, increased cytogenetic damage, and development of necrosis.
- Research Organization:
- Universitaetsklinikum Essen (Germany, F.R.)
- OSTI ID:
- 6254506
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 16:4
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARCINOMAS
RADIOTHERAPY
HEAT
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
CELL NUCLEI
DNA REPLICATION
EXPERIMENTAL NEOPLASMS
HYPERTHERMIA
MICE
NECROSIS
SYNERGISM
X RADIATION
ANIMALS
BODY TEMPERATURE
CELL CONSTITUENTS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
ENERGY
IONIZING RADIATIONS
MAMMALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEIC ACID REPLICATION
PATHOLOGICAL CHANGES
RADIATIONS
RADIOLOGY
RODENTS
THERAPY
VERTEBRATES
550603* - Medicine- External Radiation in Therapy- (1980-)
550600 - Medicine
560152 - Radiation Effects on Animals- Animals