Caffeine and human cerebral blood flow: A positron emission tomography study

Journal Article · Mon Jan 01 00:00:00 EST 1990 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(90)90174-P· OSTI ID:6253506

Cameron, O G; Modell, J G; Hariharan, M ^[1]

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1. Univ. of Michigan Medical Center, Ann Arbor (USA)

Positron emission tomography (PET) was used to quantify the effect of caffeine on whole brain and regional cerebral blood flow (CBF) in humans. A mean dose of 250 mg of caffeine produced approximately a 30% decrease in whole brain CBF; regional differences in caffeine effect were not observed. Pre-caffeine CBF strongly influenced the magnitude of the caffeine-induced decrease. Caffeine decreased p{sub a}CO{sub 2} and increased systolic blood pressure significantly; the change in p{sub a}CO{sub 2} did not account for the change in CBF. Smaller increases in diastolic blood pressure, heart rate, plasma epinephrine and norepinephrine, and subjectively reported anxiety were also observed.

• OSTI ID: 6253506
• Journal Information: Life Sciences; (USA), Vol. 47:13; ISSN 0024-3205
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
BLOOD FLOW
CAFFEINE
BIOLOGICAL EFFECTS
ADRENALINE
BLOOD PRESSURE
MAN
NORADRENALINE
POSITRON COMPUTED TOMOGRAPHY
ADRENAL HORMONES
ANALEPTICS
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
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CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
HETEROCYCLIC COMPOUNDS
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PRIMATES
PURINES
SYMPATHOMIMETICS
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