Effects of vasoactive intestinal peptide on vascular conductance are unaffected by anesthesia

Journal Article · Thu Dec 01 00:00:00 EST 1988 · American Journal of Physiology; (USA)

OSTI ID:6252501

Bouder, T G; Huffman, L J; Hedge, G A ^[1]

---

1. West Virginia Univ. Medical Center, Morgantown (USA)

In rats anesthetized with ketamine and pentobarbital (KET/PB), vasoactive intestinal peptide (VIP) increases vascular conductance (VC) in the salivary gland, pancreas, and thyroid gland, whereas no changes in VC are observed in a number of other organs. Because anesthesia may alter the responsiveness of physiological systems, we compared the effects of VIP on organ VC in conscious or anesthetized rats. Chronically catheterized rats were studied in the conscious state or 30 min after induction of anesthesia with KET/PB, isoflurane, or Inactin. Blood flows were measured by the reference sample version of the radioactive microsphere (MS) technique using two MS injections ({sup 141}Ce-MS/{sup 85}Sr-MS). Mean arterial blood pressure was monitored and used in the calculation of VC. Organ VCs were similar under basal conditions in conscious and anesthetized rats. VIP infusion caused systemic hypotension and increased VCs in the salivary gland, pancreas, and thyroid gland, and these responses were largely unaffected by anesthesia. These results indicate that the anesthetics used do not alter basal VC or the responsiveness of the vasculature to exogenous VIP.

• OSTI ID: 6252501
• Journal Information: American Journal of Physiology; (USA), Vol. 255:6; ISSN 0002-9513
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
LTH
RADIOIMMUNOASSAY
PEPTIDES
BIOLOGICAL EFFECTS
TSH
ANESTHESIA
BLOOD PRESSURE
BLOOD VESSELS
RATS
ANIMALS
BIOASSAY
BODY
CARDIOVASCULAR SYSTEM
DIAGNOSTIC TECHNIQUES
GONADOTROPINS
HORMONES
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
PROTEINS
RADIOASSAY
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
RODENTS
TRACER TECHNIQUES
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques