Dentofacial development in long-term survivors of acute lymphoblastic leukemia. A comparison of three treatment modalities

Journal Article · Sat Dec 15 00:00:00 EST 1990 · Cancer (Philadelphia); (USA)

DOI:https://doi.org/10.1002/1097-0142(19901215)66:12<2645::AID-CNCR2820661230>3.0.CO;2-S· OSTI ID:6251615

Sonis, A L; Tarbell, N; Valachovic, R W; Gelber, R; Schwenn, M; Sallan, S ^[1]

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1. Children's Hospital, Boston, MA (USA)

Ninety-seven children who were diagnosed with acute lymphoblastic leukemia before 10 years of age and treated with chemotherapy alone, chemotherapy plus 1800-cGy cranial irradiation (RT), or chemotherapy plus 2400-cGy RT were evaluated for effects of therapy on dentofacial development. All patients were seen at least 5 years postdiagnosis. Dental abnormalities were determined from panoramic radiographs, and craniofacial evaluations were made from lateral cephalometric radiographs. Ninety-one (94%) of all patients and 41 (100%) of patients younger than 5 years of age at diagnosis had abnormal dental development. The severity of these abnormalities was greater in children who received treatment before 5 years of age and in those who received RT. Observed dental abnormalities included tooth agenesis, arrested root development, microdontia, and enamel dysplasias. Craniofacial abnormalities occurred in 18 of 20 (90%) of those patients who received chemotherapy plus 2400-cGy RT before 5 years of age. Mean cephalometric values of this group showed significant deficient mandibular development. The results of this study suggest that the severity of dentofacial-developmental abnormalities secondary to antileukemia therapy are related to the age of the patient at the initiation of treatment and the use of cranial RT.

• OSTI ID: 6251615
• Journal Information: Cancer (Philadelphia); (USA), Vol. 66:12; ISSN 0008-543X
• Country of Publication: United States
• Language: English

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