Process for producing astatine-211 for radiopharmaceutical use

Patent · Tue Jul 21 00:00:00 EDT 1987

OSTI ID:6250090

Mirzadeh, S; Lambrecht, R M

A one-step chemical manipulation is described in combination with a distillation and collection process for producing At-211 comprising; a. providing a target of irradiated Bismuth coated to a predetermined thickness of a backing member, b. providing a vapor-producing still operably connected with a condenser that has a water cooled condensate collector formed of a dry silica gel mesh maintained at a temperature above the freezing point of water, and providing an effluent gas filter that is operably connected to receive effluent gas from the condenser, c. heating the target in the still at a temperature in the range of about 630/sup 0/-680/sup 0/C for a time period in the range of 50 to 80 minutes, to evole At-211 vapor from the target, c. providing a dry carrier gas having an oxygen concentration that is sufficient to form Bi/sub 2/O/sub 3/ thereby to essentially preclude vaporization of Bi metal, passing the carrier gas through the still to carry the At-211 vapor to the condenser, and to carry effluent from the condenser to the effluent gas filter, e. eluting At-211 from the condensate collector of the condenser with a controlled volume of eluent containing predetermined solvents that are compatible with a given desired radiopharmaceutical procedure, and f. collecting the At-211 in the controlled volume of eluent for use in the given radiopharmaceutical procedure.

• Assignee: Dept. of Energy, Washington, DC
• Patent Number(s): US 4681727
• OSTI ID: 6250090
• Resource Relation: Patent File Date: Filed date 10 Apr 1984
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
ASTATINE 211
CHEMICAL PREPARATION
RADIOPHARMACEUTICALS
BISMUTH
CONDENSATES
CONDENSERS
DISTILLATION
FILTERS
HEATING
HIGH TEMPERATURE
IRRADIATION
MELTING POINTS
SILICA GEL
SOLVENTS
TARGETS
THICKNESS
TIME DEPENDENCE
VAPORS
ADSORBENTS
ALPHA DECAY RADIOISOTOPES
ASTATINE ISOTOPES
BETA DECAY RADIOISOTOPES
DIMENSIONS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
FLUIDS
GASES
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
ISOTOPES
LABELLED COMPOUNDS
METALS
NUCLEI
ODD-EVEN NUCLEI
PHYSICAL PROPERTIES
RADIOISOTOPES
SEPARATION PROCESSES
SYNTHESIS
THERMODYNAMIC PROPERTIES
TRANSITION TEMPERATURE
400703* - Radiochemistry & Nuclear Chemistry- Radioisotope Production