Radical proposal for the treatment of malignant astrocytoma

Journal Article · Fri Feb 01 00:00:00 EST 1991 · American Journal of Clinical Oncology; (USA)

DOI:https://doi.org/10.1097/00000421-199102000-00017· OSTI ID:6246567

Karlsson, U; Black, P; Nair, S; Yablon, J S; Brady, L W ^[1]

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1. Hahnemann Univ., Philadelphia, PA (USA)

The traditional treatment for anaplastic astrocytoma (AAF) and glioblastoma multiforme (GBM) leads to local relapse. The recurring element is assumed to be previously radioresistant, reorganizing hypoxic cells that require up to three times the traditional photon irradiation dose for inactivation. We are proposing to coagulate the original lesion with high-dose precision brachytherapy, immediately followed by resection to save the patient from secondary effects of the necrotic region. The treatment then continues with adjuvant external beam radiation therapy to the local surrounding brain and concomitant chemotherapy. The approach inverts the traditional regimen. It has the virtue of being precise, avoiding secondary effects of the necrotic tumor, and satisfying accepted radiobiological principles.

• OSTI ID: 6246567
• Journal Information: American Journal of Clinical Oncology; (USA), Vol. 14:1; ISSN 0277-3732
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
ASTROCYTOMAS
COMBINED THERAPY
SURGERY
BRAIN
IODINE ISOTOPES
IRIDIUM ISOTOPES
RADIATION DOSES
BODY
CENTRAL NERVOUS SYSTEM
DISEASES
DOSES
GLIOMAS
ISOTOPES
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
ORGANS
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)
550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)
550900 - Pathology