Radiation-induced dural fibrosarcoma with unusually short latent period

Conference · Sat May 01 00:00:00 EDT 1993 · Journal of Neuropathology and Experimental Neurology; (United States)

OSTI ID:6246448

Ghatak, N R; Aydin, F; Leshner, R T ^[1]

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1. Medical College of Virginia, Richmond (United States) Tulane Univ., New Orleans, LA (United States)

Although rare, the occurrence of radiation-induced intracranial neoplasms of various types is well known. Among these tumors, fibrosarcomas, especially in the region of seila turcica, seem to be the most common type. These tumors characteristically occur after a long latent period, usually several years, following radiation therapy. The authors now report a case of apparently radiation-induced fibrosarcoma with some unusual features in a 10-year-old boy who was treated with radiation for medulloblastoma. He received a total dose of 53.2 Gy radiation delivered at 1.8 per fraction with 6 MV acceleration using the standard craniospinal technique. An MRI at 15 months after the completion of radiotherapy showed a mass over the cerebral convexity, which increased two-fold in size within a period of 4 months. A well circumscribed tumor was removed from the fronto-parietal convexity. The tumor measured 5x4.5x1.5 cm and was attached to the dura with invasion of the overlying bone. Histologically, it displayed the characteristic features of a low-grade fibrosarcoma. The patient remains free of tumor 18 months after the surgery. This case emphasizes the potential risk for the development of a second neoplasm following therapeutic radiation and also documents, to the authors' knowledge, the shortest latent period reported so far between administration of radiotherapy and development of an intracranial tumor.

• OSTI ID: 6246448
• Report Number(s): CONF-9306208-; CODEN: JNENAD
• Journal Information: Journal of Neuropathology and Experimental Neurology; (United States), Vol. 52:3; Conference: 69. annual meeting of the American Association of Neuropathologists (AAN), Salt Lake City, UT (United States), 10-13 Jun 1993; ISSN 0022-3069
• Country of Publication: United States
• Language: English

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BRAIN
BIOLOGICAL RADIATION EFFECTS
FIBROSARCOMAS
GROWTH
TIME DELAY
IONIZING RADIATIONS
BIOLOGICAL EFFECTS
RADIOTHERAPY
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