A functional and chemical study of radiation effects on rat parotid and submandibular/sublingual glands

Journal Article · Sat Dec 01 00:00:00 EST 1990 · Radiation Research; (USA)

DOI:https://doi.org/10.2307/3577837· OSTI ID:6245292

Vissink, A; S-Gravenmade, E J; Ligeon, E E; Konings, W T ^[1]

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1. Univ. of Groningen (Netherlands)

The aim of this study was to monitor composition and rate of secretion of rat parotid and submandibular/sublingual saliva following local single doses of X-rays ranging from 5 to 20 Gy. Pilocarpine-stimulated samples of parotid and submandibular/sublingual saliva were simultaneously collected with miniaturized Lashley cups before and 1-30 days after irradiation. The lag phase (period between injection of pilocarpine and start of the secretion) and flow rate were recorded and the concentrations of sodium, potassium, calcium, phosphate, and amylase were measured. With increasing dose and time, the salivary flow rate as well as sodium concentration decreased, while potassium concentrations increased throughout the follow-up period. The lag phase and the concentration of amylase reached their maximum at 3 and 10 days after irradiation, respectively. The changes in lag phase and flow rate were most obvious after doses of 15 or 20 Gy and showed a great similarity for parotid and submandibular/sublingual saliva. No dose-response relationship was observed for the changes in concentrations of calcium and phosphate. It is concluded that for radiation doses of 10 Gy and above, irreversible changes (lag phase, flow rate, potassium, sodium) were observed. A saturation of the irradiation effects (lag phase, flow rate) seems to exist at doses larger than 15 Gy. No significant differences were observed between the radiation-induced functional changes in parotid and submandibular/sublingual salivary gland tissue.

• OSTI ID: 6245292
• Journal Information: Radiation Research; (USA), Vol. 124:3; ISSN 0033-7587
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
SALIVARY GLANDS
BIOLOGICAL RADIATION EFFECTS
AMYLASE
DOSE-RESPONSE RELATIONSHIPS
RADIATION DOSES
RATS
TIME DEPENDENCE
X RADIATION
ANIMALS
BIOLOGICAL EFFECTS
BODY
DOSES
ELECTROMAGNETIC RADIATION
ENZYMES
GLANDS
GLYCOSYL HYDROLASES
HYDROLASES
IONIZING RADIATIONS
MAMMALS
O-GLYCOSYL HYDROLASES
ORGANS
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals