Amplification and chromosomal dispersion of human endogenous retroviral sequences
Endogenous retroviral sequences have undergone amplification events involving both viral and flanking cellular sequences. The authors cloned members of an amplified family of full-length endogenous retroviral sequences. Genomic blotting, employing a flanking cellular DNA probe derived from a member of this family, revealed a similar array of reactive bands in both humans and chimpanzees, indicating that an amplification event involving retroviral and associated cellular DNA sequences occurred before the evolutionary separation of these two primates. Southern analyses of restricted somatic cell hybrid DNA preparations suggested that endogenous retroviral segments are widely dispersed in the human genome and that amplification and dispersion events may be linked.
- Research Organization:
- National Institute of Allergy and Infectious Diseases, Bethesda, MD (USA)
- OSTI ID:
- 6243886
- Journal Information:
- J. Virol.; (United States), Vol. 59:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHROMOSOMES
GENETIC MAPPING
VIRUSES
GENE AMPLIFICATION
DNA
DNA SEQUENCING
DNA-CLONING
HYBRIDIZATION
MAN
PHOSPHORUS 32
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CLONING
DAYS LIVING RADIOISOTOPES
DNA HYBRIDIZATION
ISOTOPES
LIGHT NUCLEI
MAMMALS
MAPPING
MICROORGANISMS
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PARASITES
PHOSPHORUS ISOTOPES
PRIMATES
RADIOISOTOPES
STRUCTURAL CHEMICAL ANALYSIS
VERTEBRATES
550401* - Genetics- Tracer Techniques