Cohort mortality study of chemical workers with potential exposure to the higher chlorinated dioxins

Journal Article · Fri May 01 00:00:00 EDT 1987 · JOM, J. Occup. Med.; (United States)

OSTI ID:6240352

Ott, M G; Olson, R A; Cook, R R; Bond, G G

This cohort study evaluated mortality patterns, 1940 through 1982, of 2,192 chemical workers who, having engaged in the manufacture of higher chlorinated phenols and derivative products, had potential occupational exposures to chlorinated dioxins. Relative to United States white male mortality experience, there were no statistically significant deviations from expected for the following categories: all causes, total malignant neoplasms, or specific malignancies of particular interest: stomach cancer, liver cancer, connective and other soft-tissue cancer, the lymphomas, or nasal and nasopharyngeal cancer. For the cirrhosis of the liver category, internal comparisons demonstrated increasing trends associated with duration of employment in the Chlorophenol Production and Finishing areas; but available evidence suggests this finding was related to alcohol abuse. The study does not support a causal association between chronic human disease as measured by mortality and exposures to the higher chlorinated phenols, derivative products, or their unwanted contaminants, the chlorinated dioxins.

• Research Organization: Dow Chemical Company, Midland, MI
• OSTI ID: 6240352
• Journal Information: JOM, J. Occup. Med.; (United States), Vol. 29:5
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
CHEMICAL INDUSTRY
HEALTH HAZARDS
DIOXIN
TOXICITY
NEOPLASMS
EPIDEMIOLOGY
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
DISEASES
HAZARDS
HETEROCYCLIC COMPOUNDS
INDUSTRY
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
560300* - Chemicals Metabolism & Toxicology
550900 - Pathology