Follow-up Thallium-201 scintigraphy after mantle field radiotherapy for Hodgkin's disease

Journal Article · Fri Apr 02 00:00:00 EST 1993 · International Journal of Radiation Oncology, Biology and Physics; (United States)

DOI:https://doi.org/10.1016/0360-3016(93)90317-O· OSTI ID:6239439

Pierga, J Y; Girinski, T; Henry-Amar, M ^[1]; Maunoury, C; Valette, H; Tchernia, G; Desgrez, A ^[2]; Socie, G ^[3]; Cosset, J M ^[4]

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1. Institut Gustave Roussy, Villejuif (France)
2. Centre Hospitalier de Bicetre, Le Kremlin-Bicetre (France)
3. Institut Gustave Roussy, Villejuif (France) Hopital St Louis, Paris (France)
4. Institut Gustave Roussy, Villejuif (France) Institut Curie, Paris (France)

Assessment of the long-term cardiac effects of mediastinal radiotherapy for Hodgkin's disease, by Thallium scintigraphy. 32 patients (14 males and 18 females) who underwent mantle field radiotherapy for Hodgkin's disease were included in this study. Twenty patients received 4 fractions of 2.5 Gy per week and 12, five fraction of 2 Gy per week, delivered on alternate days. All the patients, except three, performed exercise testing electrocardiogram and Thallium-201 tomoscintigraphy. The average time interval from completion of treatment to the study was 7 years (range 3--13 years). No patients had clinical symptoms of cardiac disease. Mean age at the time of the study was 35 years (range 23--48 years). Two electrocardiograms revealed left bundle branch block and the patients were excluded from the study. Only one out of 27 exercise electrocardiograms was abnormal in a patient with mitral valve prolapse, who was also excluded from the study. Twenty-six scintigraphies were evaluable. Twenty-two (85%) were clearly abnormal with partial or complete redistribution on delayed images. The anterior region was affected in 19 of these cases (86%). Four explorations were undoubtedly normal. Coronary angiography was not performed for ethical reasons in these asymptomatic patients. Despite possible false positive tests, the high rate of abnormality (85%) in this small series is striking. These preliminary data justify larger studies and a close long-term follow-up of these patients. 24 refs., 1 fig., 2 tabs.

• OSTI ID: 6239439
• Journal Information: International Journal of Radiation Oncology, Biology and Physics; (United States), Vol. 25:5; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
HEART
POST-IRRADIATION EXAMINATION
SCINTISCANNING
HODGKINS DISEASE
RADIOTHERAPY
THALLIUM 201
ELECTROCARDIOGRAMS
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIAGRAMS
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HEAVY NUCLEI
IMMUNE SYSTEM DISEASES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LYMPHOMAS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
SECONDS LIVING RADIOISOTOPES
THALLIUM ISOTOPES
THERAPY
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550603 - Medicine- External Radiation in Therapy- (1980-)