GABA sub A (gamma-aminobutyric acid) type binding sites on membranes of spermatozoa

Journal Article · Mon Jan 01 00:00:00 EST 1990 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(90)90175-Q· OSTI ID:6230476

Erdoe, S L ^[1]; Wekerle, L ^[2]

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1. Georg-August Univ., Goettingen (West Germany)
2. Research Institute for Animal Husbandry, Herceghalom (Hungary)

The binding of ({sup 3}H) gamma-aminobutyric acid (GABA) to seminal membranes of swines and rams was examined. Specific, GABA binding was demonstrated in both species, which showed the features of GABA{sub A} type receptors. The affinity of binding was similar in both species, whereas the density of seminal GABA binding sites was 5 times higher in swine. Our findings suggest that GABA may have a direct effect on spermatozoa.

• OSTI ID: 6230476
• Journal Information: Life Sciences; (USA), Vol. 47:13; ISSN 0024-3205
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
AMINOBUTYRIC ACID
RECEPTORS
AFFINITY
BIOCHEMICAL REACTION KINETICS
CELL MEMBRANES
SHEEP
SPERMATOZOA
SWINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
AMINO ACIDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
CARBOXYLIC ACIDS
CELL CONSTITUENTS
DOMESTIC ANIMALS
DRUGS
GAMETES
GERM CELLS
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
MAMMALS
MEMBRANE PROTEINS
MEMBRANES
NEUROREGULATORS
ORGANIC ACIDS
ORGANIC COMPOUNDS
PROTEINS
REACTION KINETICS
RUMINANTS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques