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Title: Neutrophil kinetics of recombinant human granulocyte colony-stimulating factor-induced neutropenia in rats

Abstract

Single injection of recombinant human granulocyte colony-stimulating factor (rhG-CSF) immediately induced a decrease in the number of circulating neutrophils in rats. This neutropenia occurred 10 minutes after the injection but disappeared 40 minutes after injection. This transient neutropenia was dose-dependently induced by rhG-CSF and also induced by repeated injections. We studied the kinetics of circulating neutrophils in transient neutropenia. rhG-CSF markedly decreased the number of {sup 3}H-diisopropylfluorophosphate ({sup 3}H-DFP) labeled neutrophils in the circulation 10 minutes after injection but the labeled neutrophils recovered to near the control level 40 minutes after the injection. These results indicate that the neutrophil margination accounts for the neutrophenia and the marginated neutrophils return to the circulation.

Authors:
; ;  [1]
  1. Kirin Brewery Co., Ltd., Gunma (Japan)
Publication Date:
OSTI Identifier:
6230393
Resource Type:
Journal Article
Journal Name:
Life Sciences; (USA)
Additional Journal Information:
Journal Volume: 47:15; Journal ID: ISSN 0024-3205
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; GROWTH FACTORS; BIOCHEMICAL REACTION KINETICS; DOSE-RESPONSE RELATIONSHIPS; MAN; RATS; TRACER TECHNIQUES; TRITIUM COMPOUNDS; ANIMALS; HYDROGEN COMPOUNDS; ISOTOPE APPLICATIONS; KINETICS; MAMMALS; MITOGENS; ORGANIC COMPOUNDS; PRIMATES; PROTEINS; REACTION KINETICS; RODENTS; VERTEBRATES; 550201* - Biochemistry- Tracer Techniques

Citation Formats

Okada, Yuji, Kawagishi, Mayumi, and Kusaka, Masaru. Neutrophil kinetics of recombinant human granulocyte colony-stimulating factor-induced neutropenia in rats. United States: N. p., 1990. Web. doi:10.1016/0024-3205(90)90206-7.
Okada, Yuji, Kawagishi, Mayumi, & Kusaka, Masaru. Neutrophil kinetics of recombinant human granulocyte colony-stimulating factor-induced neutropenia in rats. United States. https://doi.org/10.1016/0024-3205(90)90206-7
Okada, Yuji, Kawagishi, Mayumi, and Kusaka, Masaru. 1990. "Neutrophil kinetics of recombinant human granulocyte colony-stimulating factor-induced neutropenia in rats". United States. https://doi.org/10.1016/0024-3205(90)90206-7.
@article{osti_6230393,
title = {Neutrophil kinetics of recombinant human granulocyte colony-stimulating factor-induced neutropenia in rats},
author = {Okada, Yuji and Kawagishi, Mayumi and Kusaka, Masaru},
abstractNote = {Single injection of recombinant human granulocyte colony-stimulating factor (rhG-CSF) immediately induced a decrease in the number of circulating neutrophils in rats. This neutropenia occurred 10 minutes after the injection but disappeared 40 minutes after injection. This transient neutropenia was dose-dependently induced by rhG-CSF and also induced by repeated injections. We studied the kinetics of circulating neutrophils in transient neutropenia. rhG-CSF markedly decreased the number of {sup 3}H-diisopropylfluorophosphate ({sup 3}H-DFP) labeled neutrophils in the circulation 10 minutes after injection but the labeled neutrophils recovered to near the control level 40 minutes after the injection. These results indicate that the neutrophil margination accounts for the neutrophenia and the marginated neutrophils return to the circulation.},
doi = {10.1016/0024-3205(90)90206-7},
url = {https://www.osti.gov/biblio/6230393}, journal = {Life Sciences; (USA)},
issn = {0024-3205},
number = ,
volume = 47:15,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 1990},
month = {Mon Jan 01 00:00:00 EST 1990}
}