Comparison of hyperbaric xoygen and misonidazole in fractionated irradiation of murine tumors. [/sup 137/Cs]
Journal Article
·
· Radiat. Res.; (United States)
The enhancement ratios for hyperbaric oxygen (O/sub 2/3ATA) and for misonidazole (0.3 mg/g body wt) for fractionated irradiation (5 or 10 equal doses) of two spontaneous tumors and of normal skin of the C3H mouse have been determined. Acute skin reactions were scored for mice irradiated 18 days after plucking hair from the leg. Enhancement ratios for the TCD/sub 50/ values were virtually the same for O/sub 2/3ATA and misonidazole, 1.45 to 1.55. For acute skin reaction the enhancement ratio was higher for O/sub 2/3ATA, i.e., 1.94 vs 1.54 for misonidazole.
- Research Organization:
- Massachusetts General Hospital, Boston
- OSTI ID:
- 6229295
- Journal Information:
- Radiat. Res.; (United States), Vol. 87:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
BIOLOGICAL RADIATION EFFECTS
MISONIDAZOLE
COMPARATIVE EVALUATIONS
OXYGEN
RADIOTHERAPY
SIDE EFFECTS
SKIN
CESIUM 137
FRACTIONATED IRRADIATION
GAMMA RADIATION
MICE
OXYGEN ENHANCEMENT RATIO
ALKALI METAL ISOTOPES
ANIMALS
ANTINEOPLASTIC DRUGS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CESIUM ISOTOPES
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
MAMMALS
MEDICINE
NEOPLASMS
NONMETALS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOLOGY
RADIOSENSITIZERS
RODENTS
THERAPY
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals
550603 - Medicine- External Radiation in Therapy- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
BIOLOGICAL RADIATION EFFECTS
MISONIDAZOLE
COMPARATIVE EVALUATIONS
OXYGEN
RADIOTHERAPY
SIDE EFFECTS
SKIN
CESIUM 137
FRACTIONATED IRRADIATION
GAMMA RADIATION
MICE
OXYGEN ENHANCEMENT RATIO
ALKALI METAL ISOTOPES
ANIMALS
ANTINEOPLASTIC DRUGS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CESIUM ISOTOPES
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
MAMMALS
MEDICINE
NEOPLASMS
NONMETALS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOLOGY
RADIOSENSITIZERS
RODENTS
THERAPY
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals
550603 - Medicine- External Radiation in Therapy- (1980-)