Genetic constraints in the induction of the immune response to Ehrlich ascites tumor in mice. [X ray]
A single injection of irradiated Ehrlich ascites tumor (EAT) cells induces immunity in normal mice but fails to do so in T-cell-deficient-thymectomized, lethally irradiated, bone marrow-reconstituted (TIR) mice. TIR mice injected with normal syngeneic T cells develop an immune response to EAT when injected with irradiated EAT cells and reject a subsequent tumor cell challenge. In the present studies allogeneic T cells were unable to protect against EAT in TIR recipients even if harvested from donors tolerant to the recipient's transplantation antigens and injected into the TIR mice tolerant to the transplantation antigens of the injected T cells. Tolerance was produced by establishing long-term radiation chimeras of the P ..-->.. F/sub 1/ type. Semiallogeneic T cells also failed to afford protection against EAT in TIR recipients. Whereas tolerance to other parental-strain transplantation antigens did not reverse the inability of parental T cells (cells from P ..-->.. F/sub 1/ chimeric donors) to protect against EAT in F/sub 1/ TIR mice, it did enable F/sub 1/ T cells to afford protection in P ..-->.. F/sub 1/ TIR mice.
- Research Organization:
- Oak Ridge National Lab., TN
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 6229289
- Journal Information:
- Cell. Immunol.; (United States), Vol. 62:1
- Country of Publication:
- United States
- Language:
- English
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IMMUNITY
GENETIC VARIABILITY
IMMUNOSUPPRESSION
RADIOINDUCTION
ASCITES TUMOR CELLS
BONE MARROW CELLS
LETHAL IRRADIATION
LYMPHOCYTES
MICE
RADIATION CHIMERAS
X RADIATION
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL VARIABILITY
BLOOD
BLOOD CELLS
BODY FLUIDS
CHIMERAS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
IRRADIATION
LEUKOCYTES
MAMMALS
MATERIALS
MOSAICISM
RADIATIONS
RODENTS
SOMATIC CELLS
TUMOR CELLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals