skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Inotropic effects of ethanol and dihydropyridines on the guinea pig heart atrial muscle

Abstract

The effects of ethanol and/or dihydropyridines (DHPs) on force of contraction of atrial muscle were studied. Guinea pig atrial strips superfused with Tyrode's solution were driven while recording muscle tension. Bay K 8644 (BAYK) increased, while nimodipine or ethanol reduced, the peak tension developed and the maximum velocity of development of tension. The effects of ethanol were readily reversible, but those of the DHPs were not. The combined actions of ethanol and DHPs were the result of the synergism or antagonism of the drugs tested. The shorter duration of the action of ethanol resulted in the effect of DHPs being still evident well after the exposure to the drugs ended. In summary, ethanol and nimodipine exerted depressant actions on atrial contractile force, while BAYK had opposite effects. The different mechanisms of action may explain the different duration of the effects of ethanol and DHPs.

Authors:
 [1]; ;  [2];  [3]
  1. Univ. of La Frontera, Temuco (Chile)
  2. Howard Univ., Washington, DC (USA)
  3. State Univ. of New York, Binghamton (USA)
Publication Date:
OSTI Identifier:
6225878
Resource Type:
Journal Article
Journal Name:
Life Sciences; (USA)
Additional Journal Information:
Journal Volume: 47:19; Journal ID: ISSN 0024-3205
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ETHANOL; BIOLOGICAL EFFECTS; MUSCLES; CONTRACTION; PYRIDINES; GUINEA PIGS; SYNERGISM; ALCOHOLS; ANIMALS; AZINES; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; MAMMALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RODENTS; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology

Citation Formats

Salvatici, R P, Gallardo-Carpentier, A, Carpentier, R G, and Isaacson, R L. Inotropic effects of ethanol and dihydropyridines on the guinea pig heart atrial muscle. United States: N. p., 1990. Web. doi:10.1016/0024-3205(90)90345-R.
Salvatici, R P, Gallardo-Carpentier, A, Carpentier, R G, & Isaacson, R L. Inotropic effects of ethanol and dihydropyridines on the guinea pig heart atrial muscle. United States. https://doi.org/10.1016/0024-3205(90)90345-R
Salvatici, R P, Gallardo-Carpentier, A, Carpentier, R G, and Isaacson, R L. 1990. "Inotropic effects of ethanol and dihydropyridines on the guinea pig heart atrial muscle". United States. https://doi.org/10.1016/0024-3205(90)90345-R.
@article{osti_6225878,
title = {Inotropic effects of ethanol and dihydropyridines on the guinea pig heart atrial muscle},
author = {Salvatici, R P and Gallardo-Carpentier, A and Carpentier, R G and Isaacson, R L},
abstractNote = {The effects of ethanol and/or dihydropyridines (DHPs) on force of contraction of atrial muscle were studied. Guinea pig atrial strips superfused with Tyrode's solution were driven while recording muscle tension. Bay K 8644 (BAYK) increased, while nimodipine or ethanol reduced, the peak tension developed and the maximum velocity of development of tension. The effects of ethanol were readily reversible, but those of the DHPs were not. The combined actions of ethanol and DHPs were the result of the synergism or antagonism of the drugs tested. The shorter duration of the action of ethanol resulted in the effect of DHPs being still evident well after the exposure to the drugs ended. In summary, ethanol and nimodipine exerted depressant actions on atrial contractile force, while BAYK had opposite effects. The different mechanisms of action may explain the different duration of the effects of ethanol and DHPs.},
doi = {10.1016/0024-3205(90)90345-R},
url = {https://www.osti.gov/biblio/6225878}, journal = {Life Sciences; (USA)},
issn = {0024-3205},
number = ,
volume = 47:19,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 1990},
month = {Mon Jan 01 00:00:00 EST 1990}
}