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Title: Thermal responses to 5. 6-GHz radiofrequency radiation in anesthetized rats: effect of chlorpromazine

Abstract

Anesthetized rats were exposed to 5.6-GHz continuous wave radiofrequency radiation at an average power density of 60 mW/cm2 (average specific absorption rate 12 W/kg). Exposure was performed to raise colonic temperature from 38.5 to 39.5 degrees C. Following acute administration of chlorpromazine, body temperature exhibited a faster return to baseline temperature when exposure was discontinued. When exposure was initiated at 38.5 degrees C and continued until lethal temperatures resulted, chlorpromazine-treated animals exhibited significantly shorter survival times than saline-treated animals. Thus, although chlorpromazine enhanced thermo-regulatory efficiency at colonic temperatures below 39.5 degrees C, the drug caused increased susceptibility to terminal radiofrequency radiation exposure. The present results, when compared to previous studies of irradiation at 2.8 GHz, indicate that the effects of chlorpromazine on thermal responses to RFR during intermittent and terminal exposure are similar at both 2.8 and 5.6 GHz.

Authors:
; ;
Publication Date:
Research Org.:
Air Force School of Aerospace Medicine, Brooks Air Force Base, TX (USA)
OSTI Identifier:
6210431
Resource Type:
Journal Article
Journal Name:
Physiol. Chem. Phys. Med. NMR; (United States)
Additional Journal Information:
Journal Volume: 20:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CHLORPROMAZINE; BIOLOGICAL EFFECTS; RADIOWAVE RADIATION; BODY TEMPERATURE; HEAT; RATS; SURVIVAL TIME; AMINES; ANIMALS; AZINES; CENTRAL NERVOUS SYSTEM AGENTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DRUGS; ELECTROMAGNETIC RADIATION; ENERGY; HETEROCYCLIC COMPOUNDS; HYPNOTICS AND SEDATIVES; MAMMALS; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; PHENOTHIAZINES; PSYCHOTROPIC DRUGS; RADIATIONS; RODENTS; TRANQUILIZERS; VERTEBRATES; 560400* - Other Environmental Pollutant Effects

Citation Formats

Jauchem, J R, Frei, M R, and Heinmets, F. Thermal responses to 5. 6-GHz radiofrequency radiation in anesthetized rats: effect of chlorpromazine. United States: N. p., 1988. Web.
Jauchem, J R, Frei, M R, & Heinmets, F. Thermal responses to 5. 6-GHz radiofrequency radiation in anesthetized rats: effect of chlorpromazine. United States.
Jauchem, J R, Frei, M R, and Heinmets, F. 1988. "Thermal responses to 5. 6-GHz radiofrequency radiation in anesthetized rats: effect of chlorpromazine". United States.
@article{osti_6210431,
title = {Thermal responses to 5. 6-GHz radiofrequency radiation in anesthetized rats: effect of chlorpromazine},
author = {Jauchem, J R and Frei, M R and Heinmets, F},
abstractNote = {Anesthetized rats were exposed to 5.6-GHz continuous wave radiofrequency radiation at an average power density of 60 mW/cm2 (average specific absorption rate 12 W/kg). Exposure was performed to raise colonic temperature from 38.5 to 39.5 degrees C. Following acute administration of chlorpromazine, body temperature exhibited a faster return to baseline temperature when exposure was discontinued. When exposure was initiated at 38.5 degrees C and continued until lethal temperatures resulted, chlorpromazine-treated animals exhibited significantly shorter survival times than saline-treated animals. Thus, although chlorpromazine enhanced thermo-regulatory efficiency at colonic temperatures below 39.5 degrees C, the drug caused increased susceptibility to terminal radiofrequency radiation exposure. The present results, when compared to previous studies of irradiation at 2.8 GHz, indicate that the effects of chlorpromazine on thermal responses to RFR during intermittent and terminal exposure are similar at both 2.8 and 5.6 GHz.},
doi = {},
url = {https://www.osti.gov/biblio/6210431}, journal = {Physiol. Chem. Phys. Med. NMR; (United States)},
number = ,
volume = 20:2,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1988},
month = {Fri Jan 01 00:00:00 EST 1988}
}