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Title: Polymerized liposomes containing C-glycosides of sialic acid: Potent inhibitors of influenza virus in vitro infectivity

Abstract

The surface lectin of the influenza virus, hemagglutinin, binds to terminal [alpha]-glycosides of N-acetylneuraminic acid (NeuAc) on cell-surface glycoproteins and glycolipids. Viral binding to cells expression terminal NeuAc residues can be inhibited by [alpha]-O-glycosides of NeuAc (O-sialosides). Recently, dramatic enhancements in the inhibition of viral adhesion to erythrocytes have been achieved using synthetic polyvalent sialosides. In this communication, the authors report that polymerized liposomes containing [alpha]-C-glycosides of sialic acid are potent inhibitors of influenza virus in vitro infectivity. Their results also indicate that the capacity to inhibit hemagglutination does not necessarily reflect the capacity to inhibit in vitro infectivity. 14 refs., 1 tab.

Authors:
; ; ;  [1]; ;  [2]
  1. Lawrence Berkeley Lab., CA (United States)
  2. Glycomed, Inc., Alameda, CA (United States)
Publication Date:
OSTI Identifier:
6206047
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Journal Article
Journal Name:
Journal of the American Chemical Society; (United States)
Additional Journal Information:
Journal Volume: 115:3; Journal ID: ISSN 0002-7863
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; GLYCOSIDES; SYNTHESIS; LIPOSOMES; POLYMERIZATION; ANTI-INFECTIVE AGENTS; HEMAGGLUTININS; INFLUENZA VIRUSES; SIALIC ACID; AGGLUTININS; ANTIBODIES; CARBOHYDRATES; CHEMICAL REACTIONS; DRUGS; MICROORGANISMS; MONOSACCHARIDES; ORGANIC COMPOUNDS; PARASITES; SACCHARIDES; VIRUSES; 550200* - Biochemistry; 550700 - Microbiology; 400201 - Chemical & Physicochemical Properties

Citation Formats

Spevak, W, Bednarski, M D, Nagy, J O, Charych, D H, Schaefer, M E, and Gilbert, J H. Polymerized liposomes containing C-glycosides of sialic acid: Potent inhibitors of influenza virus in vitro infectivity. United States: N. p., 1993. Web. doi:10.1021/ja00056a047.
Spevak, W, Bednarski, M D, Nagy, J O, Charych, D H, Schaefer, M E, & Gilbert, J H. Polymerized liposomes containing C-glycosides of sialic acid: Potent inhibitors of influenza virus in vitro infectivity. United States. https://doi.org/10.1021/ja00056a047
Spevak, W, Bednarski, M D, Nagy, J O, Charych, D H, Schaefer, M E, and Gilbert, J H. 1993. "Polymerized liposomes containing C-glycosides of sialic acid: Potent inhibitors of influenza virus in vitro infectivity". United States. https://doi.org/10.1021/ja00056a047.
@article{osti_6206047,
title = {Polymerized liposomes containing C-glycosides of sialic acid: Potent inhibitors of influenza virus in vitro infectivity},
author = {Spevak, W and Bednarski, M D and Nagy, J O and Charych, D H and Schaefer, M E and Gilbert, J H},
abstractNote = {The surface lectin of the influenza virus, hemagglutinin, binds to terminal [alpha]-glycosides of N-acetylneuraminic acid (NeuAc) on cell-surface glycoproteins and glycolipids. Viral binding to cells expression terminal NeuAc residues can be inhibited by [alpha]-O-glycosides of NeuAc (O-sialosides). Recently, dramatic enhancements in the inhibition of viral adhesion to erythrocytes have been achieved using synthetic polyvalent sialosides. In this communication, the authors report that polymerized liposomes containing [alpha]-C-glycosides of sialic acid are potent inhibitors of influenza virus in vitro infectivity. Their results also indicate that the capacity to inhibit hemagglutination does not necessarily reflect the capacity to inhibit in vitro infectivity. 14 refs., 1 tab.},
doi = {10.1021/ja00056a047},
url = {https://www.osti.gov/biblio/6206047}, journal = {Journal of the American Chemical Society; (United States)},
issn = {0002-7863},
number = ,
volume = 115:3,
place = {United States},
year = {Wed Feb 10 00:00:00 EST 1993},
month = {Wed Feb 10 00:00:00 EST 1993}
}