Alcohol consumption, Lewis phenotypes, and risk of ischemic heart disease

Journal Article · Sat Feb 13 00:00:00 EST 1993 · Lancet; (United States)

DOI:https://doi.org/10.1016/0140-6736(93)92987-5· OSTI ID:6202021

Hein, H O; Suadicani, P; Gyntelberg, F ^[1]; Sorenson, H ^[2]; Hein, H O ^[3]

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1. Rigshospitalet State Univ. Hospital, Copenhagen (Denmark). Epidemiological Research Unit
2. Rigshospitalet State Univ. Hospital, Copenhagen (Denmark). Dept. of Chemical Immunology
3. Univ. of Copenhagen (Denmark). Dept. of Internal Medicine

The authors have previously found an increased risk of ischemic heart disease (IHD) in men with the Lewis phenotype Le(a[minus]b[minus]) and suggested that the Lewis blood group has a close genetic relation with insulin resistance. The authors have investigated whether any conventional risk factors explain the increased risk in Le(a[minus]b[minus]) men. 3,383 men aged 53-75 years were examined in 1985-86, and morbidity and mortality during the next 4 years were recorded. At baseline, the authors excluded 343 men with a history of myocardial infarction, angina pectoris, intermittent claudication, or stroke. The potential risk factors examined were alcohol consumption, physical activity, tobacco smoking, serum cotinine, serum lipids, body-mass index, blood pressure, prevalence of hypertension and non-insulin-dependent diabetes mellitus, and social class. In 280 (9.6%) men with Le(a[minus]b[minus]), alcohol was the only risk factor significantly associated with risk of IHD. There was a significant inverse dose-effect relation between alcohol consumption and risk; trend tests, with adjustment for age, were significant for fatal IHD (p=0.02), all IHD (p=0.03), and all causes of death (p=0.02). In 2649 (90.4%) men with other phenotypes, there was a limited negative association with alcohol consumption. In Le(a[minus]b[minus]) men, a group genetically at high risk of IHD, alcohol consumption seems to be especially protective. The authors suggest that alcohol consumption may modify insulin resistance in Le(a[minus]b[minus]) men.

• OSTI ID: 6202021
• Journal Information: Lancet; (United States), Vol. 341:8842; ISSN 0099-5355
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ETHANOL
BIOLOGICAL EFFECTS
ISCHEMIA
PATHOGENESIS
BLOOD PRESSURE
DOSE-RESPONSE RELATIONSHIPS
INSULIN
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