Gangliosides, or sialic acid, antagonize ethanol intoxication

Journal Article · Fri Jan 01 00:00:00 EST 1988 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(88)90284-6· OSTI ID:6201467

Klemm, W R; Boyles, R; Matthew, J; Cherian, L

Because ethanol elicits a dose-dependent hydrolysis of brain sialogangliosides, the authors tested the possibility that injected gangliosides might antagonize intoxicating doses of ethanol. Clear anti-intoxication effects were seen at 24 hr post-injection of mixed mouse-brain gangliosides at 125-130 mg/kg, but not at lower or higher doses. Sleep time was reduced on the order of 50%, and roto-rod agility was significantly enhanced. Sialic acid (SA) similarly antagonized ethanol; however, the precursor of SA, N-acetyl-D-mannosamine, as well as ceramide and asialoganglioside did not.

• Research Organization: Texas A and M Univ., College Station (USA)
• OSTI ID: 6201467
• Journal Information: Life Sci.; (United States), Vol. 43:22
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ETHANOL
TOXICITY
GANGLIOSIDES
BIOLOGICAL EFFECTS
SIALIC ACID
BRAIN
DOSE-RESPONSE RELATIONSHIPS
MICE
ALCOHOLS
ANIMALS
BODY
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
GLYCOLIPIDS
HYDROXY COMPOUNDS
LIPIDS
MAMMALS
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
RODENTS
SACCHARIDES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology