Scintigraphic localization of pheochromocytoma

Journal Article · Thu Jul 02 00:00:00 EDT 1981 · New Engl. J. Med.; (United States)

DOI:https://doi.org/10.1056/NEJM198107023050103· OSTI ID:6201334

Sisson, J C; Frager, M S; Valk, T W; Gross, M D; Swanson, D P; Wieland, D M; Tobes, M C; Beierwaltes, W H; Thompson, N W

We used a new radiopharmaceutical agent, (/sup 131/I)meta-iodobenzylguanidine ((/sup 131/I)MIBG), to produce scintigraphic images of pheochromocytomas in eight patients. One day or more after injection, the only normal organ that displayed distinct concentrations of radioactivity was the urinary bladder. The (/sup 131/I)MIBG was probably concentrated in adrenergic vesicles; in tissues where vesicles are numerous, such as pheochromocytomas, the radionuclide was retained for days. Tumors in four patients were not detected by computed tomography. In one patient, reoperation was undertaken only because the scintigram located the extra-adrenal tumors and thereby directed the surgeon's exploration. The method offers hope of safe and reliable localization of pheochromocytomas in their many guises.

• Research Organization: Univ. of Michigan, Ann Arbor
• OSTI ID: 6201334
• Journal Information: New Engl. J. Med.; (United States), Vol. 305:1
• Country of Publication: United States
• Language: English

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