Nasopharyngeal cancer: study II
The actuarial survival rtes, recurrence rates and complication frequencies in 2 studies of nasopharyngeal cancer of different treatment modalities are compared. Study I was comprised of 1605 patients treated in a uniform schedule throughout 15 years from 1958 through 1973. This report is the second study, comprised of another 1032 patients treated during the period of 1974 to 1978. These patients were treated by 3 modalities, namely: (1) the conventional 35 fractionated total dose of 7000 rad in 7 to 8 weeks; (2) the split-course of the same dose with an interruption of about 10 days in the middle of the treatment; and (3) the split-course of the same dose and adjuvant cyclophosphamide with an average dose of 4900 mg in 4 to 5 weeks. The patient populations were more or less similar in the 2 studies, except in study II the tumors were more anaplastic in histology and in an earlier stage. The comparison revealed positive results with improved overall actuarial survival rates, less recurrences, and reduced post-radiation complications. Systemic spread remained the cause of failure in this disease. Adjuvant chemotherapy either in a large dose or a small stimulating dose is suggested in further study.
- OSTI ID:
- 6190611
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 7:6; Conference: International head and neck oncology research conference, Rosslyn, VA, USA, 8 Sep 1980
- Country of Publication:
- United States
- Language:
- English
Similar Records
Preliminary results of radiation dose escalation for locally advanced nasopharyngeal carcinoma
Preoperative hyperfractionated chemoradiation for locally recurrent rectal cancer in patients previously irradiated to the pelvis: A multicentric phase II study
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
NEOPLASMS
BIOLOGICAL RADIATION EFFECTS
PHARYNX
RADIOTHERAPY
SIDE EFFECTS
COMPARATIVE EVALUATIONS
DOSE RATES
ENDOXAN
FRACTIONATED IRRADIATION
HISTOLOGY
PATIENTS
RADIATION DOSES
RADIOSENSITIVITY
TIME DEPENDENCE
ALKYLATING AGENTS
BIOLOGICAL EFFECTS
BODY
DIGESTIVE SYSTEM
DISEASES
DOSES
DRUGS
IMMUNOSUPPRESSIVE DRUGS
IRRADIATION
MEDICINE
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOLOGY
RESPIRATORY SYSTEM
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man