Radionuclide diagnosis of allograft rejection

Journal Article · Fri Oct 01 00:00:00 EDT 1982 · Semin. Nucl. Med.; (United States)

DOI:https://doi.org/10.1016/S0001-2998(82)80017-2· OSTI ID:6190578

George, E A

Interaction with one or more anatomical and physiopathological characteristics of the rejecting renal allograft is suggested by those radioagents utilized specifically for the diagnosis of allograft rejection. Rejection, the most common cause of declining allograft function, is frequently mimicked clinically or masked by other immediate or long term post transplant complications. Understanding of the anatomical pathological features and kinetics of rejection and their modification by immunosuppressive maintenance and therapy are important for the proper clinical utilization of these radioagents. Furthermore, in selecting these radionuclides, one has to consider the comparative availability, preparatory and procedural simplicity, acquisition and display techniques and the possibility of timely report. The clinical utilities of radiofibrinogen, /sup 99m/Tc sulfur colloid and /sup 67/Ga in the diagnosis of allograft rejection have been evaluated to a variable extent in the past. The potential usefulness of the recently developed preparations of /sup 111/In labeled autologous leukocytes and platelets are presently under investigation.

• Research Organization: VA Medical Center, Saint Louis University, MO
• OSTI ID: 6190578
• Journal Information: Semin. Nucl. Med.; (United States), Vol. 12:4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
GALLIUM 67
DIAGNOSTIC USES
GRAFT-HOST REACTION
DIAGNOSIS
INDIUM 111
TECHNETIUM 99
TRANSPLANTS
BLOOD PLATELETS
FIBRINOGEN
GRAFTS
ISOMERIC NUCLEI
KIDNEYS
LEUKOCYTES
PATHOLOGY
PATIENTS
RADIOCOLLOIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD COAGULATION FACTORS
BODY
BODY FLUIDS
COAGULANTS
COLLOIDS
DAYS LIVING RADIOISOTOPES
DISPERSIONS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM ISOTOPES
GLOBULINS
HEMATOLOGIC AGENTS
HEMOSTATICS
HOURS LIVING RADIOISOTOPES
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
TECHNETIUM ISOTOPES
USES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics