Enhancement of the white matter following prophylactic therapy of the central nervous system for leukemia

Journal Article · Sat Aug 01 00:00:00 EDT 1981 · Radiology; (United States)

OSTI ID:6189005

Shalen, P R; Ostrow,; T, P; Glass, P J

A case of fatal necrotizing leukoencephalopathy following prophylactic therapy of the central nervous system for acute lymphoblastic leukemia is reported. The clinical, CT, and neuropathological findings are described. The CT scan demonstrated symmetrical white-matter enhancement. Histological analysis was consistent with the effects of irradiation and methotrexate. The differential diagnosis of the clinical and CT findings is discussed. Brain biopsy is the diagnostic procedure of choice.

• Research Organization: Univ. of Texas, Houston
• OSTI ID: 6189005
• Journal Information: Radiology; (United States), Vol. 140:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
DELAYED RADIATION EFFECTS
METHOTREXATE
RADIOSENSITIVITY EFFECTS
MYELITIS
RADIOINDUCTION
NECROSIS
NERVES
RADIOTHERAPY
SIDE EFFECTS
ADOLESCENTS
BIOPSY
CAT SCANNING
DIAGNOSTIC TECHNIQUES
FRACTIONATED IRRADIATION
HISTOLOGICAL TECHNIQUES
LEUKEMIA
PARTIAL BODY IRRADIATION
PATIENTS
AGE GROUPS
ANTIMETABOLITES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DISEASES
DRUGS
EXTERNAL IRRADIATION
HEMIC DISEASES
IMAGE PROCESSING
IRRADIATION
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
PROCESSING
RADIATION EFFECTS
RADIOLOGY
THERAPY
TOMOGRAPHY
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550603 - Medicine- External Radiation in Therapy- (1980-)