Pulmonary toxicity of cyclophosphamide: a 1-year study
The development of cyclophosphamide-induced pulmonary lesions over a 1-year period was studied in mice. Male BALB/c mice received a single intraperitoneal injection of 100 mg/kg of cyclophosphamide. Within 3 weeks there were scattered foci of intraalveolar foamy macrophages. With time, these foci increased in size and, 1 year later, occupied large areas in all lung lobes. There was also diffuse interstitial fibrosis. Chemical determination done 3, 12, 24, and 52 weeks after cyclophosphamide showed that lungs of animals treated with cyclophosphamide had significantly more hydroxyproline per lung than controls. One year after cyclophosphamide pressure - volume curves measured in vivo were shifted down and to the right and total lung volumes were decreased. A single injection of cyclophosphamide produced an irreversible and progressive pulmonary lesion. 16 references, 5 figures, 3 tables.
- Research Organization:
- OaK Ridge National Lab., TN
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 6185714
- Journal Information:
- Exp. Mol. Pathol.; (United States), Vol. 42
- Country of Publication:
- United States
- Language:
- English
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ENDOXAN
TOXICITY
LUNGS
FIBROSIS
EXPERIMENTAL DATA
INTRAPERITONEAL INJECTION
MACROPHAGES
MICE
ALKYLATING AGENTS
ANIMAL CELLS
ANIMALS
BODY
CONNECTIVE TISSUE CELLS
DATA
DRUGS
IMMUNOSUPPRESSIVE DRUGS
INFORMATION
INJECTION
INTAKE
MAMMALS
NUMERICAL DATA
ORGANS
PATHOLOGICAL CHANGES
PHAGOCYTES
RESPIRATORY SYSTEM
RODENTS
SOMATIC CELLS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)