Thyroid hormones increase Na -H exchange activity in renal brush border membranes

Journal Article · Sat Jun 01 00:00:00 EDT 1985 · Proc. Natl. Acad. Sci. U.S.A.; (United States)

DOI:https://doi.org/10.1073/pnas.82.11.3606· OSTI ID:6181749

Kinsella, J; Sacktor, B

Na -H exchange activity, i.e., amiloride-sensitive Na and H flux, in renal proximal tubule brush border (luminal) membrane vesicles was increased in the hyperthyroid rat and decreased in the hypothyroid rat, relative to the euthyroid animal. A positive correlation was found between Na -H exchange activity and serum concentrations of thyroxine (T4) and triiodothyronine (T3). The thyroid status of the animal did not alter amiloride-insensitive Na uptake. The rate of passive pH gradient dissipation was higher in membrane vesicles from hyperthyroid rats compared to the rate in vesicles from hypothyroid animals, a result which would tend to limit the increase in Na uptake in vesicles from hyperthyroid animals. Na -dependent phosphate uptake was increased in membrane vesicles from hyperthyroid rats; Na -dependent D-glucose and L-proline uptakes were not changed by the thyroid status of the animal. The effect of thyroid hormones in increasing the uptake of Na in the brush border membrane vesicle is consistent with the action of the hormones in enhancing renal Na reabsorption.

• Research Organization: National Institute of Health Gerontology Research Center, Baltimore, MD
• OSTI ID: 6181749
• Journal Information: Proc. Natl. Acad. Sci. U.S.A.; (United States), Vol. 82:11
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
PHOSPHORUS 32
MEMBRANE TRANSPORT
SODIUM 22
THYROXINE
BIOLOGICAL EFFECTS
TRIIODOTHYRONINE
TRITIUM COMPOUNDS
CELL MEMBRANES
GLUCOSE
HYPERTHYROIDISM
HYPOTHYROIDISM
KIDNEYS
PH VALUE
PHOSPHATES
PROLINE
RATS
ALDEHYDES
ALKALI METAL ISOTOPES
AMINES
AMINO ACIDS
ANIMALS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CARBOXYLIC ACIDS
CELL CONSTITUENTS
DAYS LIVING RADIOISOTOPES
DISEASES
ENDOCRINE DISEASES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HEXOSES
HORMONES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MEMBRANES
MONOSACCHARIDES
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PEPTIDE HORMONES
PHOSPHORUS COMPOUNDS
PHOSPHORUS ISOTOPES
PYRROLES
PYRROLIDINES
RADIOISOTOPES
RODENTS
SACCHARIDES
SODIUM ISOTOPES
THYROID HORMONES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550201* - Biochemistry- Tracer Techniques