A human pseudoautosomal gene encodes the ANT3 ADP/ATP translocase and escapes X-inactivation

Journal Article · Thu Apr 01 00:00:00 EST 1993 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1135· OSTI ID:6180019

Slim, R ^[1]; Levilliers, J; Petit, C ^[2]; Luedecke, H J; Horsthemke, B ^[3]; Claussen, U ^[4]; Nguyen, V C ^[5]; Gough, N M ^[6]

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1. Institut Pasteur, Paris (France) Institut Gustave Roussy, Villejuif (France)
2. Institut Pasteur, Paris (France)
3. Universitaetsklinikum, Essen (Germany)
4. Universitaet Erlangen (Germany)
5. Institut Gustave Roussy, Villejuif (France)
6. Post Office Royal Melbourne Hospital, Parkville (Australia)

The authors report that the human ANT3 ADP/ATP translocase gene is [alpha] pseudoautosomal gene located proximal to the GM-CSF receptor a chain gene (CSF2RA). An ANT3-homologous locus, likely corresponding to a pseudogene, maps to chromosome 9. The ANT3 gene is transcribed from the centromere to the telomere and contains in its first intron a CpG island mapped 1300 kb from the telomere. This gene is transcribed from the Y chromosome and from the active and inactive X chromosomes. This gene thus escapes X-inactivation as predicted for genes belonging to the pseudoautosomal region. 61 refs., 5 figs., 1 tab.

• OSTI ID: 6180019
• Journal Information: Genomics; (United States), Vol. 16:1; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ATP
TRANSLOCATION
HUMAN X CHROMOSOME
INACTIVATION
MAPPING
HUMAN Y CHROMOSOME
MEMBRANE PROTEINS
GENES
ADP
MITOCHONDRIA
CELL CONSTITUENTS
CHROMOSOMES
HETEROCHROMOSOMES
HUMAN CHROMOSOMES
NUCLEOTIDES
ORGANIC COMPOUNDS
PROTEINS
X CHROMOSOME
Y CHROMOSOME
550400* - Genetics